The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Treatment of Infections Caused by Metronidazole-Resistant Trichomonas vaginalis
Open accessAbstract
SUMMARY: Infections with the sexually transmitted protozoan Trichomonas vaginalis are usually treated with metronidazole, a 5-nitroimidazole drug derived from the antibiotic azomycin. Metronidazole treatment is generally efficient in eliminating T. vaginalis infection and has a low risk of serious side effects. However, studies have shown that at least 5% of clinical cases of trichomoniasis are caused by parasites resistant to the drug. The lack of approved alternative therapies for T. vaginalis treatment means that higher and sometimes toxic doses of metronidazole are the only option for patients with resistant disease. Clearly, studies of the treatment and prevention of refractory trichomoniasis are essential. This review describes the mechanisms of metronidazole resistance in T. vaginalis and provides a summary of trichomonicidal and vaccine candidate drugs.
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Clinical and Microbiological Aspects of Trichomonas vaginalis
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Self-citationNitroimidazole drugs-action and resistance mechanisms I. Mechanism of action
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Drug Targets and Mechanisms of Resistance in the Anaerobic Protozoa
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Trichomonas vaginalis: Reevaluation of Its Clinical Presentation and Laboratory Diagnosis
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Antitrichomonad Action, Mutagenicity, and Reduction of Metronidazole and Other Nitroimidazoles
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Metadata
- Authors
- Cudmore, S. L., Delgaty, K. L., Hayward-McClelland, S. F., Petrin, D. P., & Garber, G. E.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2004-10
- Volume
- 17
- Issue
- 4
- Pages
- 783-793
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2097304393
- Cited by
- 306
- References
- 52
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- green
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