Cited by 205Fungal Infections and StudiesAntifungal resistance and susceptibilityImmune responses and vaccinations

The DOI matches its Crossref record; 316 of the 319 references it cites were found in a registry or an index.

Coccidioidomycosis: Host Response and Vaccine Development

Open access

Cox, Rebecca A., Magee, D. Mitchell·2004·Clinical Microbiology Reviews

DOI 10.1128/cmr.17.4.804-839.2004PMC PMC523560

Open this paper in CoChat — free account

Abstract

SUMMARY: Coccidioidomycosis is caused by the dimorphic fungi in the genus Coccidioides. These fungi live as mycelia in the soil of desert areas of the American Southwest, and when the infectious spores, the arthroconidia, are inhaled, they convert into the parasitic spherule/endospore phase. Most infections are mild, but these organisms are frank pathogens and can cause severe lethal disease in fully immunocompetent individuals. While there is increased risk of disseminated disease in certain racial groups and immunocompromised persons, the fact that there are hosts who contain the initial infection and exhibit long-term immunity to reinfection supports the hypothesis that a vaccine against these pathogens is feasible. Multiple studies have shown that protective immunity against primary disease is associated with T-helper 1 (Th-1)-associated immune responses. The single best vaccine in animal models, formalin-killed spherules (FKS), was tested in a human trial but was not found to be significantly protective. This result has prompted studies to better define immunodominant Coccidioides antigen with the thought that a subunit vaccine would be protective. These efforts have defined multiple candidates, but the single best individual immunogen is the protein termed antigen 2/proline-rich antigen (Ag2/PRA). Studies in multiple laboratories have shown that Ag2/PRA as both protein and genetic vaccines provides significant protection against mice challenged systemically with Coccidioides. Unfortunately, compared to the FKS vaccine, it is significantly less protective as measured by both assays of reduction in fungal CFU and assays of survival. The capacity of Ag2/PRA to induce only partial protection was emphasized when animals were challenged intranasally. Thus, there is a need to define new candidates to create a multivalent vaccine to increase the effectiveness of Ag2/PRA. Efforts of genomic screening using expression library immunization or bioinformatic approaches to identify new candidates have revealed at least two new protective proteins, expression library immunization antigen 1 (ELI-Ag1) and a β-1,3-glucanosyltransferase (GEL-1). In addition, previously discovered antigens such as Coccidioides-specific antigen (CSA) should be evaluated in assays of protection. While studies have yet to be completed with combinations of the current candidates, the hypothesis is that with increased numbers of candidates in a multivalent vaccine, there will be increased protection. As the genome sequences of the two Coccidioides strains which are under way are completed and annotated, the effort to find new candidates can increase to provide a complete genomic scan for immunodominant proteins. Thus, much progress has been made in the discovery of subunit vaccine candidates against Coccidioides and there are several candidates showing modest levels of protection, but for complete protection against pulmonary challenge we need to continue the search for additional candidates.

Integrity signals

Registry

Crossref · 10.1128/cmr.17.4.804-839.2004

Cites

316 of 316 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 1×
“Recent studies have shown that unmethylated CpG triggers innate immunity through TLR9 (139).”
Background
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
The International SNP Map Working Group, Laboratories:, C. S. H., Sachidanandam, R., Weissman, D., Schmidt, S. C., Kakol, J. M., Stein, L. D., National Center for Biotechnology Information:, Marth, G., Sherry, S., et al. (2001) · Nature · doi:10.1038/35057149 · Cited by 2,977
Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice
Flynn, J. L., Goldstein, M. M., Chan, J., Triebold, K. J., Pfeffer, K., Lowenstein, C. J., Schrelber, R., Mak, T. W., & Bloom, B. R. (1995) · Immunity · doi:10.1016/1074-7613(95)90001-2 · Cited by 1,678
Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.
Le, J., & Vilček, J. (1987) · PubMed · Cited by 1,327
The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection
Kindler, V., Sappino, A., Grau, G. E., Piguet, P., & VASSALLI, P. (1989) · Cell · doi:10.1016/0092-8674(89)90676-4 · Cited by 1,239
Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
Cella, M., Engering, A. J., Pinet, V., Pieters, J., & Lanzavecchia, A. (1997) · Nature · doi:10.1038/42030 · Cited by 1,123
The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses
Sallusto, F., Mackay, C. R., & Lanzavecchia, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.593 · Cited by 1,054
Dendritic Cell Subsets and Lineages, and Their Functions in Innate and Adaptive Immunity
Liu, Y.-J. (2001) · Cell · doi:10.1016/s0092-8674(01)00456-1 · Cited by 1,021
RESPONSE OF CULTURED MACROPHAGES TO MYCOBACTERIUM TUBERCULOSIS , WITH OBSERVATIONS ON FUSION OF LYSOSOMES WITH PHAGOSOMES
Armstrong, J. A., & Hart, P. D. (1971) · The Journal of Experimental Medicine · doi:10.1084/jem.134.3.713 · Cited by 991

Show all 319 references

Research works printed but not linked: 23

Albert E. D. M. R. Mickey and P. I. Terasaki. 1973. Genetics of the HLA system in four populations: American-Caucasians Japanese-Americans American Negroes and Mexican Americans p. 233-240. In J. Dausett and J. Colombani (ed.) Histocompatibility testing. The Williams & Wilkins Co. Baltimore Md.
Beaman L. and D. Pappagianis. 1985. Fate of Coccidioides immitis arthroconidia in human peripheral blood monocyte cultures in vitro p. 170-180. In H. Einstein and A. Catanzaro (ed.) Coccidioidomycosis. Proceedings of the 4th International Conference. National Foundation for Infectious Disease Washington D.C.
Brummer E. L. Beaman and D. A. Stevens. 1985. Killing of endospores but not arthroconididia of Coccidioides immitis by immunologically activated polymorphoneclear neutrophils p. 201-213. In H. Einstein and A. Catanzaro (ed.) Coccidioidomycosis. Proceedings of the 4th International Conference. National Foundation for Infectious Disease Washington D.C.
Cole, G. T., C.-Y. Hung, and N. Delgado. 2002. Parasite phase-specific gene expression in Coccidioides. ASM News68:603-610.
Currah, R. S. 1985. Taxonomy of Onygenales: Arthrodermataceae. Gymnoascacease. Myxotrichaceae, and Onygenaceae. Mycotaxon24:1-216.
Department of Health and Human Services. 2002. Possession, use, and transfer of select agents and toxins. 42 CFR, Part 73. Fed. Regist.240:76886-76905.
Dodge R. R. M. D. Lebowitz R. A. Barbee and B. Burrows. 1985. Immediate reactions to coccidioidin and spherulin: the relation of atopy to coccidioidomycosis p. 214-223. In H. Einstein and A. Catanzaro (ed.) Coccidioidomycosis. Proceedings of the 4th International Conference. National Foundation for Infectious Disease Washington D.C.
Drutz, D. J., and A. Catanzaro. 1978. Coccidioidomycosis. Part II. State of the art. Am. Rev. Respir. Dis.117:727-770.
Galgiani J. N. 1985. Potential role of human polymorphonuclear leukocytes in the early host response to Coccidioides immitis p. 181-190. In H. Einstein and A. Catanzaro (ed.) Coccidioidomycosis. Proceedings of the 4th International Conference. National Foundation for Infectious Diseases Washington D.C.
Hicks H. R. and W. T. Northey. 1967. Studies on the response of thymectomized mice to infection with Coccidioides immitis p. 183-187. In L. Ajello (ed.) Proceedings of Second Coccidioidomycosis Symposium. University of Arizona Press Tucson.
Kirkland T. N. and J. Fierer. 1986. Genetics of resistance to coccidioidomycosis p. 169-171. In L. Leive (ed.) Microbiology—1986. American Society for Microbiology Washington D.C.
Kong Y. M. and H. B. Levine. 1967. Loss and recovery of virulence of arthrospores and spherule- endospores of Coccidioides immitis in live vaccines p. 189-195. In L. Ajello (ed.) Proceedings of the Second Coccidioidomycosis Symposium. University of Arizona Press Tucson.
Mourant A. E. A. C. Kopec and D. S. Kazmiera. 1959. The ABO blood groups. Blackwell Scientific Publishing Oxford United Kingdom.
Ophuls, W., and H. C. Moffitt. 1900. A new pathogenic mould (formerly described as a protozoon: Coccidioides immitis pyogenes) preliminary report. Philadelphia Med. J.5:1471-1472.
Payne R. K. K. Kidd P. Rodvany and H. H. Perkins. 1973. HL-A and other polymorphisms of the Filipino people p. 203-208. In J. Dausett and J. Colombani (ed.) Histocompatibility testing. The Williams & Wilkins Co. Baltimore Md.
Posadas, A. 1892. Un nuevo caso de micosis fungoidea con psorospermias. An. Circ. Med. Argent.15:585-597.
Rea T. H. H. Einstein R. Johnson and N. E. Levan. 1977. Further study of dinitrochlorobenzene responsivity in disseminated coccidioidomycosis p. 365-370. In L. Ajello (ed.) Coccidioidomycosis: current clinical and diagnostic status. Symposia Specialists Miami Fla.
Rixford, E., and T. C. Gilchrist. 1896. Two cases of protozoan (coccidioidal) infection of the skin and other organs. Johns Hopkins Hosp. Rev.1:209-268.
Segal G. P. and A. Catanzaro. 1985. Genetic regulation of antibody responses to Coccidioides immitis: the role of antibody in mediated immunity p. 191-200. In H. Einstein and A. Catanzaro (ed.) Coccidioidomycosis. Proceedings of the 4th International Conference. National Foundation for Infectious Disease Washington D.C.
Sievers M. L. 1977. Prognostic factors in disseminated coccidioidomycosis among southwestern American Indians p. 63-78. In L. Ajello (ed.) Coccidioidomycosis: current clinical and diagnostic status. Symposia Specialists Miami Fla.
Wernicke, R. 1892. Ueber einen Protozoenbefund bei Mycosis fungoides. Zentbl. Bakteriol.12:859-861.
Winn W. A. 1967. A working classification of coccidioidomycosis and its application to therapy p. 3-9. In L. Ajello (ed.) Proceedings of the Second Coccidioidomycosis Symposium. University of Arizona Press Tucson.
Winn W. A. S. M. Finegold and R. W. Huntington. 1967. Coccidioidomycosis with fungemia p. 93-109. In L. Ajello (ed.) Proceedings of the Second Coccidioidomycosis Symposium. University of Arizona Press Tucson.

Sorted by citations

2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis
Galgiani, J. N., Ampel, N. M., Blair, J. E., Catanzaro, A., GEERTSMA, F. R., Hoover, S. E., Johnson, R. H., Kusne, S., LISSE, J. R., MacDonald, J. D., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw360 · Cited by 635
Fungi that Infect Humans
Köhler, J. R., Hube, B., Puccia, R., Casadevall, A., & Perfect, J. R. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0014-2016 · Cited by 318
Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis
Nguyen, C. T. Q., Barker, B. M., Hoover, S. E., Nix, D. E., Ampel, N. M., Frelinger, J. A., Orbach, M. J., & Galgiani, J. N. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00005-13 · Cited by 270
Advances in combating fungal diseases: vaccines on the threshold
Cutler, J. E., Deepe, G. S., & Klein, B. S. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1537 · Cited by 223
Donor-Derived Fungal Infections in Organ Transplant Recipients: Guidelines of the American Society of Transplantation, Infectious Diseases Community of Practice
Singh, N., Huprikar, S. S., Burdette, S. D., Morris, M. I., Blair, J. E., & Wheat, L. J. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04100.x · Cited by 190
Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon controlPreprint
Neafsey, D. E., Barker, B. M., Sharpton, T. J., Stajich, J., Park, D. J., Whiston, E., Hung, C.-Y., McMahan, C. A., White, J. R., Sykes, S. M., et al. (2010) · Genome Research · doi:10.1101/gr.103911.109 · Cited by 189
Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts
Blair, J. E., Coakley, B. J., Santelli, A. C. F. E. S., Hentz, J. G., & Wengenack, N. L. (2006) · Mycopathologia · doi:10.1007/s11046-006-0062-5 · Cited by 161
Coccidioidomycosis: A review and update
DiCaudo, D. J. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.04.039 · Cited by 125
Fungal vaccines: real progress from real challenges
Cassone, A. (2008) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(08)70016-1 · Cited by 115
Virulence Regulation of Phytopathogenic Fungi by pH
Alkan, N., Espeso, E. A., & Prusky, D. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5062 · Cited by 113
Immunotherapy for Fungal Infections
Segal, B. H., Kwon‐Chung, J., Walsh, T. J., Klein, B. S., Battiwalla, M., Almyroudis, N. G., Holland, S. M., & Romani, L. R. (2006) · Clinical Infectious Diseases · doi:10.1086/499811 · Cited by 111
Coccidioidomycosis in Dogs and Cats: A Review
Graupmann-Kuzma, A., Valentine, B. A., Shubitz, L. F., Dial, S. M., Watrous, B. J., & Tornquist, S. J. (2008) · Journal of the American Animal Hospital Association · doi:10.5326/0440226 · Cited by 106
A Genetically Engineered Live Attenuated Vaccine of Coccidioides posadasii Protects BALB/c Mice against Coccidioidomycosis
Xue, J., Chen, X., Selby, D. M., Hung, C.-Y., Yu, J., & Cole, G. T. (2009) · Infection and Immunity · doi:10.1128/iai.00459-09 · Cited by 103
Interleukin-12 Receptor 1 Deficiency Predisposing to Disseminated Coccidioidomycosis
Vinh, D. C., Schwartz, B., Hsu, A. P., Miranda, D. J., Valdez, P. A., Fink, D. L., Lau, K., Long-Priel, D., Kuhns, D. B., Uzel, G., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq215 · Cited by 100
Treatment of Refractory Coccidioidomycosis With Voriconazole or Posaconazole
Kim, M. M., Vikram, H. R., Kusne, S., Seville, M. T., & Blair, J. E. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir642 · Cited by 99
Animal models: an important tool in mycology
Capilla, J., Clemons, K. V., & Stevens, D. A. (2007) · Medical Mycology · doi:10.1080/13693780701644140 · Cited by 94
Local Population Structure and Patterns of Western Hemisphere Dispersal for Coccidioides spp., the Fungal Cause of Valley Fever
Engelthaler, D. M., Roe, C. C., Hepp, C. M., Teixeira, M. D. M., Driebe, E. M., Schupp, J. M., Gade, L., Waddell, V. G., Komatsu, K. K., Arathoon, E., et al. (2016) · mBio · doi:10.1128/mbio.00550-16 · Cited by 89
Vaccine Immunity to Coccidioidomycosis Occurs by Early Activation of Three Signal Pathways of T Helper Cell Response (Th1, Th2, and Th17)
Hung, C.-Y., González, Á., Wüthrich, M., Klein, B. S., & Cole, G. T. (2011) · Infection and Immunity · doi:10.1128/iai.05726-11 · Cited by 87
Coccidioidomycosis in Persons Infected with HIV Type 1
Ampel, N. M. (2005) · Clinical Infectious Diseases · doi:10.1086/444502 · Cited by 87
Construction and Evaluation of a Novel Recombinant T Cell Epitope-Based Vaccine against Coccidioidomycosis
Hurtgen, B. J., Hung, C.-Y., Ostroff, G. R., Levitz, S. M., & Cole, G. T. (2012) · Infection and Immunity · doi:10.1128/iai.00566-12 · Cited by 80
Susceptibility to Coccidioides species in C57BL/6 mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a)
Jiménez-A, M. D. P., Viriyakosol, S., Walls, L., Datta, S. K., Kirkland, T. N., Heinsbroek, S. E. M., Brown, G. D., & Fierer, J. (2008) · Genes and Immunity · doi:10.1038/gene.2008.23 · Cited by 83
Virulence Mechanisms of Coccidioides
Hung, C.-Y., Xue, J., & Cole, G. T. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1406.020 · Cited by 77
Vaccines for invasive fungal infections
Spellberg, B. J. (2011) · F1000 Medicine Reports · doi:10.3410/m3-13 · Cited by 75
Characteristics of Patients with Mild to Moderate Primary Pulmonary Coccidioidomycosis
Blair, J. E., Chang, Y.-H. H., Cheng, M., Vaszar, L. T., Vikram, H. R., Orenstein, R., Kusne, S., Ho, S., Seville, M. T., & Parish, J. M. (2014) · Emerging infectious diseases · doi:10.3201/eid2006.131842 · Cited by 73
Coccidioidomycosis in African Americans
Ruddy, B. E., Mayer, A. P., Ko, M. G., Labonte, H. R., Borovansky, J. A., Boroff, E. S., & Blair, J. E. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0423 · Cited by 65
Developing a vaccine against aspergillosis
Stevens, D. A., Clemons, K. V., & Liu, M. (2010) · Medical Mycology · doi:10.3109/13693786.2010.497775 · Cited by 65
Coccidioidomycosis in liver transplantation
Blair, J. E. (2005) · Liver Transplantation · doi:10.1002/lt.20654 · Cited by 65
Coccidioidomycosis in selected immunosuppressed hosts
Blair, J. E., Ampel, N. M., & Hoover, S. E. (2018) · Medical Mycology · doi:10.1093/mmy/myy019 · Cited by 64
Detection and phylogenetic analysis of Coccidioides posadasii in Arizona soil samples
Barker, B. M., Tabor, J. A., Shubitz, L. F., Perrill, R., & Orbach, M. J. (2011) · Fungal ecology · doi:10.1016/j.funeco.2011.07.010 · Cited by 62
Coccidioides Endospores and Spherules Draw Strong Chemotactic, Adhesive, and Phagocytic Responses by Individual Human Neutrophils
Lee, C.-Y., Thompson, G. R., Hastey, C. J., Hodge, G., Lunetta, J. M., Pappagianis, D., & Heinrich, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129522 · Cited by 60
An agonist of human complement fragment C5a enhances vaccine immunity against Coccidioides infection
Hung, C.-Y., Hurtgen, B. J., Bellecourt, M. J., Sanderson, S. D., Morgan, E. L., & Cole, G. T. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.04.084 · Cited by 59
Coccidioidal meningitis: Update on epidemiology, clinical features, diagnosis, and management
Blair, J. E. (2009) · Current Infectious Disease Reports · doi:10.1007/s11908-009-0043-1 · Cited by 59
Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies
Boniche-Alfaro, C., Rossi, S. A., Kischkel, B., Barbalho, F. V., Moura, Á. N. D., Nosanchuk, J. D., Travassos, L. R., & Taborda, C. P. (2020) · Journal of Fungi · doi:10.3390/jof6010031 · Cited by 59
Saccharomyces cerevisiae as a vaccine against coccidioidomycosis
Capilla, J., Clemons, K. V., Liu, M., Levine, H. B., & Stevens, D. A. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.03.030 · Cited by 58
Race and ethnicity: Risk factors for fungal infections?
Jenks, J. D., Aneke, C. I., Al-Obaidi, M. M., Egger, M., Garcia, L., Gaines, T., Hoenigl, M., & Thompson, G. R. (2023) · PLOS Pathogens · doi:10.1371/journal.ppat.1011025 · Cited by 55
A review of innate and adaptive immunity to coccidioidomycosis
Hung, C.-Y., Hsu, A. P., Holland, S. M., & Fierer, J. (2018) · Medical Mycology · doi:10.1093/mmy/myy146 · Cited by 54
The immune response in Coccidioidomycosis
Borchers, A. T., & Gershwin, M. E. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.08.010 · Cited by 51
The Prevention of Recrudescent Coccidioidomycosis After Solid Organ Transplantation
Blair, J. E., Kusne, S., Carey, E. J., & Heilman, R. L. (2007) · Transplantation · doi:10.1097/01.tp.0000260143.54103.0d · Cited by 50
Approach to the solid organ transplant patient with latent infection and disease caused by Coccidioides species
Blair, J. E. (2008) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e3283073828 · Cited by 49
Protein Expression Profiling of Coccidioides posadasii by Two-Dimensional Differential In-Gel Electrophoresis and Evaluation of a Newly Recognized Peroxisomal Matrix Protein as a Recombinant Vaccine Candidate
Orsborn, K. I., Shubitz, L. F., Peng, T., Kellner, E. M., Orbach, M. J., Haynes, P. A., & Galgiani, J. N. (2006) · Infection and Immunity · doi:10.1128/iai.74.3.1865-1872.2006 · Cited by 49
Reactivation of Coccidioidomycosis Despite Antifungal Prophylaxis in Solid Organ Transplant Recipients
Keckich, D. W., Blair, J. E., Vikram, H. R., Seville, M. T., & Kusne, S. (2011) · Transplantation · doi:10.1097/tp.0b013e31821c1df6 · Cited by 49
Comparative Phylogenomics of Pathogenic and Nonpathogenic Species
Whiston, E., & Taylor, J. W. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.022806 · Cited by 48
The Population Biology ofCoccidioides
Barker, B. M., Jewell, K. A., Kroken, S., & Orbach, M. J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1406.040 · Cited by 47
Immune Response to Coccidioidomycosis and the Development of a Vaccine
Castro-Lopez, N., & Hung, C.-Y. (2017) · Microorganisms · doi:10.3390/microorganisms5010013 · Cited by 46
Universal fungal prophylaxis and risk of coccidioidomycosis in liver transplant recipients living in an endemic area
Kahn, A., Carey, E. J., & Blair, J. E. (2014) · Liver Transplantation · doi:10.1002/lt.24055 · Cited by 43
Natural History of Disseminated Coccidioidomycosis: Examination of the Veterans Affairs–Armed Forces Database
Bays, D. J., Thompson, G. R., Reef, S. E., Snyder, L. S., Freifeld, A., Huppert, M., Salkin, D., Wilson, M., & Galgiani, J. N. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1154 · Cited by 42
Interleukin-1 Receptor but Not Toll-Like Receptor 2 Is Essential for MyD88-Dependent Th17 Immunity to Coccidioides Infection
Hung, C.-Y., Jiménez-Alzate, M. D. P., González, Á., Wüthrich, M., Klein, B. S., & Cole, G. T. (2014) · Infection and Immunity · doi:10.1128/iai.01579-13 · Cited by 42
Early Events in Coccidioidomycosis
Donovan, F., Shubitz, L. F., Powell, D. A., Orbach, M. J., Frelinger, J. A., & Galgiani, J. N. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00112-19 · Cited by 44
RNA Sequencing-Based Genome Reannotation of the DermatophyteArthroderma benhamiaeand Characterization of Its Secretome and Whole Gene Expression Profile during Infection
Tran, V. D. T., Coi, N. D., Feuermann, M., Schmid‐Siegert, E., Băguţ, E.-T., Mignon, B. R., Waridel, P., Peter, C., Pradervand, S., Pagni, M., et al. (2016) · mSystems · doi:10.1128/msystems.00036-16 · Cited by 39
Valley fever: danger lurking in a dust cloud
Johnson, L., Gaab, E. M., Sanchez, J., Bui, P. Q., Nobile, C. J., Hoyer, K. K., Peterson, M. W., & Ojcius, D. M. (2014) · Microbes and Infection · doi:10.1016/j.micinf.2014.06.011 · Cited by 38
Coccidioidomycosis: Epidemiology, Fungal Pathogenesis, and Therapeutic Development
Hernandez, H., Erives, V. H., & Martinez, L. R. (2019) · Current Tropical Medicine Reports · doi:10.1007/s40475-019-00184-z · Cited by 38
Development of a rapid, cost-effective TaqMan Real-Time PCR Assay for identification and differentiation of Coccidioides immitis and Coccidioides posadasii
Sheff, K. W., York, E. R., Driebe, E. M., Barker, B. M., Rounsley, S. D., Waddell, V. G., Beckstrom‐Sternberg, S. M., Beckstrom‐Sternberg, J. S., Keim, P., & Engelthaler, D. M. (2009) · Medical Mycology · doi:10.1080/13693780903218990 · Cited by 37
Card9- and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection
Hung, C.-Y., Castro-Lopez, N., & Cole, G. T. (2016) · Infection and Immunity · doi:10.1128/iai.01066-15 · Cited by 37
The Quest for a Vaccine Against Coccidioidomycosis: A Neglected Disease of the Americas
Kirkland, T. N. (2016) · Journal of Fungi · doi:10.3390/jof2040034 · Cited by 36
Efficacy of Antigen 2/Proline-Rich Antigen cDNA-Transfected Dendritic Cells in Immunization of Mice against Coccidioides posadasii
Awasthi, S., Awasthi, V., Magee, D. M., & Coalson, J. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3900 · Cited by 36
Self-citation
Early Treatment With Fluconazole May Abrogate the Development of IgG Antibodies in Coccidioidomycosis
Thompson, G. R., Lunetta, J. M., Johnson, S. M., Taylor, S. L., Bays, D. J., Cohen, S. H., & Pappagianis, D. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir466 · Cited by 36
Twelve years of coccidioidomycosis in Ceará State, Northeast Brazil: epidemiologic and diagnostic aspects
Cordeiro, R. D. A., Brilhante, R. S. N., Rocha, M. F. G., Bandeira, S. P., Fechine, M. A. B., Camargo, Z. P. D., & Sidrim, J. J. C. (2008) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2008.09.016 · Cited by 35
Two cases illustrating successful adjunctive interferon-γ immunotherapy in refractory disseminated coccidioidomycosis
Duplessis, C. A., Tilley, D. H., Bavaro, M. F., Hale, B., & Holland, S. M. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.07.006 · Cited by 35
Coccidioidomycosis and Lung Transplantation
Vikram, H. R., Dosanjh, A., & Blair, J. E. (2011) · Transplantation · doi:10.1097/tp.0b013e31822e6e9a · Cited by 34
Evaluation of Two Homologous Proline-Rich Proteins of Coccidioides posadasii as Candidate Vaccines against Coccidioidomycosis
Herr, R. A., Hung, C.-Y., & Cole, G. T. (2007) · Infection and Immunity · doi:10.1128/iai.00807-07 · Cited by 33
Coccidioides Species: A Review of Basic Research: 2022
Kirkland, T. N., Stevens, D. A., Hung, C.-Y., Beyhan, S., Taylor, J. W., Shubitz, L. F., Duttke, S. H. C., Heidari, A., Johnson, R. H., Deresinski, S. C., et al. (2022) · Journal of Fungi · doi:10.3390/jof8080859 · Cited by 33
Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Differentiation of the Dimorphic Fungal Species Paracoccidioides brasiliensis and Paracoccidioides lutzii
de Almeida, J. N., Negro, G. M. B. D., Grenfell, R. C., VIDAL, M. S. M., Thomaz, D. Y., de Figueiredo, D. S. Y., Bagagli, E., Juliano, L., & Benard, G. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.02847-14 · Cited by 33
Adjuvants and delivery systems for antifungal vaccines: Current state and future developments
Portuondo, D. L., Ferreira, L. S., Urbaczek, A. C., Batista-Duharte, A., & Carlos, I. Z. (2014) · Medical Mycology · doi:10.1093/mmy/myu045 · Cited by 33
CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection
Campuzano, A., Zhang, H., Ostroff, G. R., Dias, L. D. S., Wüthrich, M., Klein, B. S., Yu, J., Lara, H. H., Lopez-Ribot, J. L., & Hung, C.-Y. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900793 · Cited by 32
Differential Thermotolerance Adaptation between Species of Coccidioides
Mead, H., Hamm, P. S., Shaffer, I. N., Teixeira, M. D. M., Wendel, C. S., Wiederhold, N. P., Thompson, G. R., Muñiz‐Salazar, R., Castañón-Olivares, L. R., Keim, P., et al. (2020) · Journal of Fungi · doi:10.3390/jof6040366 · Cited by 32
Opportunistic fungi and fungal infections: the challenge of a single, general antifungal vaccine
Cassone, A., & Torosantucci, A. (2006) · Expert Review of Vaccines · doi:10.1586/14760584.5.6.859 · Cited by 32
[Coccidioidomycosis in Argentina, 1892-2009].
Canteros, C. E., Toranzo, A., Ibarra-Camou, B., David, V., Carrizo, S. G., Santillán-Iturres, A., Serrano, J., Fernández, N., Capece, P., Gorostiaga, J., et al. (2010) · PubMed · doi:10.1590/s0325-75412010000400004 · Cited by 32
Coccidioidomycosis in Elderly Persons
Blair, J. E., Mayer, A. P., Currier, J. T., Files, J. A., & Wu, Q. F. (2008) · Clinical Infectious Diseases · doi:10.1086/593192 · Cited by 32
Experimental Animal Models of Coccidioidomycosis
Clemons, K. V., Capilla, J., & Stevens, D. A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1406.029 · Cited by 32
Linear Epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As Vaccine Candidates
Travassos, L. R., & Taborda, C. P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00224 · Cited by 31
Role of B Cells in Vaccine-Induced Immunity against Coccidioidomycosis
Magee, D. M., Friedberg, R. L., Woitaske, M. D., Johnston, S. A., & Cox, R. A. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.7011-7013.2005 · Cited by 31
Self-citation
Sex Differences in Susceptibility to Coccidioidomycosis
McHardy, I. H., Reagan, K. L., Sebastian, J. F., Barker, B. M., Bays, D. J., Dandekar, S., Cohen, S. H., Jennings, K. E., Sykes, J. E., & Thompson, G. R. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab543 · Cited by 26
Rapid diagnosis of coccidioidomycosis by nested PCR assay of sputum
Cordeiro, R. D. A., Brilhante, R. S. N., Rocha, M. F. G., Mourn, F. E. A., Camargo, Z. P. D., & Sidrim, J. J. C. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01679.x · Cited by 26
A Chronic Murine Disease Model of Coccidioidomycosis Using Coccidioides posadasii, Strain 1038
Shubitz, L. F., Powell, D. A., Butkiewicz, C. D., Lewis, M. L., Trinh, H. T., Frelinger, J. A., Orbach, M. J., & Galgiani, J. N. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa419 · Cited by 24
Coccidioidomycosis in Persons Infected with HIV‐1
Ampel, N. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1406.033 · Cited by 24
Safety, Antigenicity, and Efficacy of a Recombinant Coccidioidomycosis Vaccine in Cynomolgus Macaques (Macaca fascicularis)
JOHNSON, S. M., Lerche, N. W., Pappagianis, D., Yee, J. L., Galgiani, J. N., & Hector, R. F. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1406.042 · Cited by 23
Nitric oxide synthase activity has limited influence on the control of Coccidioides infection in mice
González, Á., Hung, C.-Y., & Cole, G. T. (2011) · Microbial Pathogenesis · doi:10.1016/j.micpath.2011.03.013 · Cited by 23
Parasitic polymorphism of Coccidioidesspp
Muñoz-Hernández, B., Palma-Cortés, G., Cabello-Gutiérrez, C., & Martínez-Rivera, M. Á. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-213 · Cited by 23
Changing Epidemiology of Classical and Emerging Human Fungal Infections: A Review
Abu‐Elteen, K. H., & Hamad, M. A. (2012) · Cited by 23
Cutaneous, Subcutaneous and Systemic Mycology
Samanta, I. (2015) · Springer eBooks · doi:10.1007/978-81-322-2280-4_4 · Cited by 23
Vaccine development for pathogenic fungi: current status and future directions
Chechi, J. L., da Costa, F. A. C., Figueiredo, J., de Souza, C. M., Valdez, A. F., Zamith‐Miranda, D., Camara, A. C., Taborda, C. P., & Nosanchuk, J. D. (2023) · Expert Review of Vaccines · doi:10.1080/14760584.2023.2279570 · Cited by 23
Progress Toward a Human Vaccine Against Coccidioidomycosis
Cole, G. T., Hurtgen, B. J., & Hung, C.-Y. (2012) · Current Fungal Infection Reports · doi:10.1007/s12281-012-0105-y · Cited by 22
Protein targets for broad‐spectrum mycosis vaccines: quantitative proteomic analysis of Aspergillus and Coccidioides and comparisons with other fungal pathogens
Champer, J., Díaz-Arévalo, D., Champer, M., Hong, T., Wong, M., Schwalb, M. E., Ito, J. I., Clemons, K. V., Stevens, D. A., & Kalkum, M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06761.x · Cited by 21
A chromosomal-level reference genome of the widely utilized Coccidioides posadasii laboratory strain “Silveira”
Teixeira, M. D. M., Stajich, J., Sahl, J. W., Thompson, G. R., Brem, R. B., Dubin, C. A., Blackmon, A. V., Mead, H., Keim, P., & Barker, B. M. (2022) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkac031 · Cited by 23
Synthesis and in vitro antifungal activity of isoniazid-derived hydrazones against Coccidioides posadasii
Cordeiro, R. D. A., de Melo, C. V. S., Marques, F. J. D. F., Serpa, R., Evangelista, A. J. D. J., Caetano, É. P., Mafezoli, J., de Oliveira, M. D. C. F., da Silva, M. R., Bandeira, T. D. J. P. G., et al. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.06.022 · Cited by 20
In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine
Vilekar, P., Awasthi, V., Lagisetty, P., King, C. J., Shankar, N., & Awasthi, S. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-60 · Cited by 20
Disseminated Coccidioidomycosis in Pregnancy
Hooper, J. E., Lu, Q., & Pepkowitz, S. H. (2007) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2007-131-652-dcip · Cited by 20
Coccidioidomycosis and Histoplasmosis in Equines: An Overview to Support the Accurate Diagnosis
Brilhante, R. S. N., Vago, P. B., de Lima, R. A. C., Castelo‐Branco, D. D. S. C. M., de Oliveira, J. S., Pinheiro, A. D. Q., Cordeiro, R. D. A., Camargo, Z. P. D., Sidrim, J. J. C., & Rocha, M. F. G. (2016) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2016.02.230 · Cited by 19
Vaccines to Prevent Coccidioidomycosis: A Gene-Deletion Mutant of Coccidioides Posadasii as a Viable Candidate for Human Trials
Galgiani, J. N., Shubitz, L. F., Orbach, M. J., Mandel, M. A., Powell, D. A., Klein, B. S., Robb, E. J., Ohkura, M., Seka, D. J., Tomasiak, T. M., et al. (2022) · Journal of Fungi · doi:10.3390/jof8080838 · Cited by 19
Dendritic Cell‐Based Vaccine against Coccidioides Infection
Awasthi, S. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1406.013 · Cited by 18
Differences in Host Innate Responses among Coccidioides Isolates in a Murine Model of Pulmonary Coccidioidomycosis
Lewis, E. R. G., David, V. R., Doyle, A., Rajabi, K., Kiefer, J., Pirrotte, P., & Barker, B. M. (2015) · Eukaryotic Cell · doi:10.1128/ec.00122-15 · Cited by 18
Epidemiological, clinical, and genomic landscape of coccidioidomycosis in northeastern Brazil
Eulálio, K. D., Kollath, D. R., Martins, L. M. S., Filho, A. D. D., Cavalcanti, M. D. A. S., Moreira, L. M., Tenório, B. G., Alves, L. G. D. B., Yamauchi, D. H., Barrozo, L. V., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47388-0 · Cited by 17
Preclinical identification of vaccine induced protective correlates in human leukocyte antigen expressing transgenic mice infected with Coccidioides posadasii
Hurtgen, B. J., Castro-Lopez, N., Jiménez-Alzate, M. D. P., Cole, G. T., & Hung, C.-Y. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.08.078 · Cited by 17
Fungal vaccines and immunotherapy
Segal, E., & Elad, D. (2006) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2006.06.004 · Cited by 17
The role of reactive oxygen intermediates in experimental coccidioidomycois in mice
Margolis, D. A., Viriyakosol, S., Fierer, J., & Kirkland, T. N. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-71 · Cited by 17
A Recombinant Multivalent Vaccine (rCpa1) Induces Protection for C57BL/6 and HLA Transgenic Mice against Pulmonary Infection with Both Species of Coccidioides
Campuzano, A., Pentakota, K. D., Liao, Y.-R., Zhang, H., Wiederhold, N. P., Ostroff, G. R., & Hung, C.-Y. (2024) · Vaccines · doi:10.3390/vaccines12010067 · Cited by 16
Yeast and Fungal Polysaccharides
Ohno, N. (2007) · Elsevier eBooks · doi:10.1016/b978-044451967-2/00132-x · Cited by 16
Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings
Koistinen, K. A., Mullaney, L. C., Bell, T. M., Zaki, S. R., Nalça, A., Frick, O. M., Livingston, V. A., Robinson, C. G., Estep, J. S., Batey, K. L., et al. (2018) · Veterinary Pathology · doi:10.1177/0300985818787306 · Cited by 16
Does the presence of mediastinal adenopathy confer a risk for disseminated infection in immunocompetent persons with pulmonary coccidioidomycosis?
Mayer, A. P., Morris, M. F., Panse, P. M., Ko, M. G., Files, J. A., Ruddy, B. E., & Blair, J. E. (2012) · Mycoses · doi:10.1111/j.1439-0507.2012.02224.x · Cited by 16
Fungi that Infect Humans
Köhler, J. R., Hube, B., Puccia, R., Casadevall, A., & Perfect, J. R. (2017) · ASM Press eBooks · doi:10.1128/9781555819583.ch39 · Cited by 18

Authors: Cox, R. A., & Magee, D. M.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
Venue: Clinical Microbiology Reviews
Publisher: American Society for Microbiology
Published: 2004-10
Volume: 17
Issue: 4
Pages: 804-839
ISSN: 0893-8512 (ISSN-L)
1098-6618
DOI: 10.1128/cmr.17.4.804-839.2004
PMC: PMC523560
OpenAlex: W2153910927
Cited by: 205
References: 319
Citations by year: 2026: 2 · 2025: 6 · 2024: 4 · 2023: 15 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 8 · 2014: 12 · 2013: 4 · 2012: 13
FWCI: 1.79
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Clinical Microbiology Reviews (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: coccidioidomycosis, Coccidioides, Th1 response, immunodominant antigens, multivalent vaccine, host immune response
MeSH terms: Animals, Antibodies, Fungal, Antigens, Fungal, Coccidioides, Coccidioidomycosis, Fungal Vaccines, Humans

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Coccidioidomycosis: Host Response and Vaccine Development

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks