High Resistance to Oxidative Stress in the Fungal Pathogen Candida glabrata Is Mediated by a Single Catalase, Cta1p, and Is Controlled by the Transcription Factors Yap1p, Skn7p, Msn2p, and Msn4p
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We characterized the oxidative stress response of Candida glabrata to better understand the virulence of this fungal pathogen. C. glabrata could withstand higher concentrations of H(2)O(2) than Saccharomyces cerevisiae and even Candida albicans. Stationary-phase cells were extremely resistant to oxidative stress, and this resistance was dependent on the concerted roles of stress-related transcription factors Yap1p, Skn7p, and Msn4p. We showed that growing cells of C. glabrata were able to adapt to high levels of H(2)O(2) and that this adaptive response was dependent on Yap1p and Skn7p and partially on the general stress transcription factors Msn2p and Msn4p. C. glabrata has a single catalase gene, CTA1, which was absolutely required for resistance to H(2)O(2) in vitro. However, in a mouse model of systemic infection, a strain lacking CTA1 showed no effect on virulence.
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The oxidative stress response in C. glabrata is regulated by the sole catalase CgCta1, two superoxide dismutases CgSod1 and CgSod2, and glutathione biosynthetic enzymes CgGsh1 and CgGsh2.
“The environmental stress response in C. glabrata is governed by two transcriptional regulators CgMsn2 and CgMsn4 [38], while the oxidative stress response is regulated by the sole catalase CgCta1 [80], two superoxide dismutases CgSod1 and CgSod2 [81], and glutathione biosynthetic enzymes CgGsh1 and CgGsh2 [82,83].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [80]
Despite an essential role of CgCta1 in resistance to hydrogen peroxide-generated oxidative stress in vitro, the Cgcta1Δ mutant was not attenuated for virulence in the murine disseminated candidiasis model.
“Despite an essential role of CgCta1 in resistance to the hydrogen peroxide-generated oxidative stress in vitro, the Cgcta1Δ mutant was not attenuated for virulence in the murine disseminated candidiasis model which suggests the existence of a CgCta1-independent resistance mechanism in vivo [80].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [80]
CgCTA1 expression is regulated by several stress response transcriptional regulators including CgYap1, CgMsn2, CgMsn4 and CgSkn7.
“CgCTA1 expression is regulated by several stress response transcriptional regulators including CgYap1, CgMsn2, CgMsn4 and CgSkn7 [80,84,85,86].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [80]
A CgCta1-independent resistance mechanism exists in vivo.
“Despite an essential role of CgCta1 in resistance to the hydrogen peroxide-generated oxidative stress in vitro, the Cgcta1Δ mutant was not attenuated for virulence in the murine disseminated candidiasis model which suggests the existence of a CgCta1-independent resistance mechanism in vivo [80].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [80]
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References 78 · Cited by 190
- Authors
- Cuéllar-Cruz, M., Briones-Martin-del-Campo, M., Cañas-Villamar, I., Montalvo-Arredondo, J., Riego-Ruiz, L., Castaño, I., & De Las Peñas, A.
- Affiliations
- División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México
- Institute for Scientific and Technological Research (MX)
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2008-05
- Volume
- 7
- Issue
- 5
- Pages
- 814-825
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- PMC
- PMC2394966
- OpenAlex
- W2161971164
- Cited by
- 190
- References
- 78
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 26 · 2021: 12 · 2020: 9 · 2019: 13 · 2018: 9 · 2017: 10 · 2016: 6 · 2015: 19 · 2014: 9 · 2013: 13 · 2012: 4
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eukaryotic Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Candida glabrata, oxidative stress resistance, catalase, hydrogen peroxide, Yap1p, Msn2p, adaptive response, fungal virulence, systemic infection
- MeSH terms
- Amino Acid Sequence, Animals, Candida albicans, Candidiasis, Catalase, Fungal Proteins, Humans, Hydrogen Peroxide, Mice, Inbred BALB C, Molecular Sequence Data, Saccharomyces cerevisiae, Transcription Factors, Virulence, Gene Expression Regulation, Fungal, Sequence Alignment, Sequence Deletion, Oxidative Stress, Candida glabrata, Mice
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