Mechanisms of Resistance to Oxidative and Nitrosative Stress: Implications for Fungal Survival in Mammalian Hosts
Open accessAbstract
The ability of a fungal pathogen to cause disease requires the ability to survive in the host. Survival in the host is dependent on evasion of the host's immune system, including the microbial killing mechanisms of phagocytes. The innate immune system is comprised of macrophages and neutrophils,
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Tsa1 was among the most highly upregulated genes following SNP+SHAM treatment.
“For example, Tsa1 (thioredoxin peroxidase 1), which provides resistance to reactive nitrogen species and has also been shown to contribute to fungal virulence (65), was among the most highly upregulated genes following SNP+SHAM treatment.”
From Inhibition of Classical and Alternative Modes of Respiration in <i>Candida albicans</i> Leads to Cell Wall Remodeling and Increased Macrophage Recognition (2019) · cites this paper as [65]
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References 187 · Cited by 223
- Authors
- Missall, T. A., Lodge, J. K., & McEwen, J. E.
- Affiliations
- Saint Louis University (US)
- Central Arkansas Veterans Healthcare System (US)
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2004-08
- Volume
- 3
- Issue
- 4
- Pages
- 835-846
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- PMC
- PMC500878
- OpenAlex
- W2117216625
- Cited by
- 223
- References
- 187
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 10 · 2023: 9 · 2022: 16 · 2021: 15 · 2020: 12 · 2019: 8 · 2018: 14 · 2017: 13 · 2016: 12 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 9
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eukaryotic Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- National Institute on Aging (P01AG020641)
- National Institute of Allergy and Infectious Diseases (R01AI051209)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- oxidative stress resistance, nitrosative stress, fungal pathogens, innate immune evasion, phagocyte killing, macrophages, neutrophils, host-pathogen interaction
- MeSH terms
- Animals, Enzymes, Fungal Proteins, Humans, Phagocytes, Yeasts, Reactive Oxygen Species, Oxidative Stress, Reactive Nitrogen Species
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