Novel Assay To Characterize Neutrophil Responses to Oral Biofilms
Open accessAbstract
Neutrophils, the most numerous leukocytes, play an important role in maintaining oral health through interactions with oral microbial biofilms. Both neutrophil hyperactivity and the bacterial subversion of neutrophil responses can cause inflammation-mediated tissue damage like that seen in periodontal disease.
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The relationship between BOP and oral inflammation is inconsistent and appears to rely on the microbial nature of the biofilm.
“Nonetheless, the presence of BOP might be indicative of underlying inflammation; however, the relationship between BOP and oral inflammation is inconsistent and appears to rely on the microbial nature of the biofilm. 25 , 38 , 39”
From Prognostic utility of oral neutrophil counts in high-risk periodontitis: A retrospective study (2025) · cites this paper as [38]
The Discussion reports that neutrophil responses vary among oral biofilms, supporting the point that microbial composition can affect inflammatory responses. But this in vitro study does not examine bleeding on probing (BOP) or establish that its relationship with oral inflammation is inconsistent. The indexed passages provide no page numbers. (LLM, conf=0.85)
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References 62 · Cited by 30
- Authors
- Oveisi, M., Shifman, H., Fine, N., Sun, C., Glogauer, N., Senadheera, D., & Glogauer, M.
- Affiliations
- University of Toronto (CA)
- Mount Sinai Hospital (CA)
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2019-02
- Volume
- 87
- Issue
- 2
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC6346121
- OpenAlex
- W2900552673
- Cited by
- 30
- References
- 62
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 2
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- neutrophil activation, dental plaque, phagocytosis, reactive oxygen species, Nrf2, neutrophil extracellular traps, myeloperoxidase, species-specific immune response, oral commensal bacteria, oral pathogens
- MeSH terms
- Biological Assay, Flow Cytometry, Humans, Peroxidase, Neutrophils, Periodontal Diseases, Phagocytosis, Streptococcal Infections, Biomarkers, Antigens, CD, Bacteroidaceae Infections, Pasteurellaceae Infections, Reactive Oxygen Species, Neutrophil Activation, Biofilms, NF-E2-Related Factor 2, Host-Pathogen Interactions
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