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Plasmid-linked ampicillin resistance in haempohilus influenza type b
Open accessAbstract
Four ampicillin-resistant, beta-lactamase-producing strains of Haempohilus influenzae type b were examined for the presence of plasmid deoxyribonucleic acid (DNA). Three resistant strains contained a 30 x 10-6-dalton (30Mdal) plasmid and one resitant strain contained a 3-Mdal plasmid. The ampicillin-sensitive Haemophilus strains examined did not contain plasmid DNA. Transformation of a sensitive H. influenzae strain to ampicillin resistance with isolated plasmid DNA preparations revealed that the structural gene for beta-lactamase resided on both plasmid species. DNA-DNA hybridization studies showed that the 30-Mdal Haemophilus plasmid contained the ampicillin translocation DNA segment (TnA) found on some R-factors of enteric origin of the H. influenzae plasmids.
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Cited by
Three Decades of β-Lactamase Inhibitors
Drawz, S. M., & Bonomo, R. A. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00037-09 · Cited by 1,709
Metadata
- Authors
- Elwell, L. P., De Graaff, J., Seibert, D., & Falkow, S.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1975-08
- Volume
- 12
- Issue
- 2
- Pages
- 404-410
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2109451548
- Cited by
- 165
- References
- 0
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Elwell, L. P., De Graaff, J., Seibert, D., & Falkow, S. (1975). Plasmid-linked ampicillin resistance in haempohilus influenza type b. Infection and Immunity. https://doi.org/10.1128/iai.12.2.404-410.1975
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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