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New Surface-Associated Heat-Labile Colonization Factor Antigen (CFA/II) Produced by Enterotoxigenic Escherichia coli of Serogroups O6 and O8
Open accessAbstract
Enterotoxigenic Escherichia coli (ETEC) belonging to serogroups O6 and O8 do not possess the H-10407-type colonization factor antigen (CFA/I). However, these frequently isolated ETEC were found to possess a second and distinct heat-labile surface-associated colonization factor antigen, termed CFA/II. Whereas CFA/I mediates mannose-resistant hemagglutination of human group A erythrocytes, CFA/II does not. CFA/II mediates mannose-resistant hemagglutination of bovine erythrocytes, and mannose-resistant hemagglutination is rapid only at reduced temperature (4°C). Because CFA/II, like CFA/I, is spontaneously lost by many ETEC isolates in the laboratory, it was possible to produce specific anti-CFA/II serum by preparing antiserum against living cells of a prototype strain (PB-176) and adsorbing this serum with living and heat-treated cells of its CFA/II-negative derivative strain PB-176-P. This serum, which neutralized the colonization factor activity of CFA/II-positive strains in infant rabbits, was employed to confirm the presence of CFA/II on ETEC which exhibited mannose-resistant hemagglutination of bovine but not human erythrocytes. CFA/II, like CFA/I, mediates adherence of the bacteria to the mucosal surface of the small intestine, as demonstrated by indirect immunofluorescence. CFA/II appears to be an important virulence factor for humans since CFA/II-positive ETEC are frequently isolated from diarrhea cases, particularly travelers' diarrhea, in Mexico; these ETEC were not uncommon in a collection of isolates from Bangladesh. The O6:H16 strain of ETEC responsible for an outbreak of diarrhea in the United States was also shown to be CFA/II positive. CFA/I and CFA/II were never found on the same serotypes of ETEC, but 98% of the heat-stable and heat-labile enterotoxin-producing ETEC belonging to the frequently isolated serogroups O6, O8, O15, O25, O63, and O78 were positive for either CFA/I or CFA/II.
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Citations
Cited by
Beachey, E. H. (1981) · Journal of Infectious Diseases · doi:10.1093/infdis/143.3.325 · Cited by 1,411
2 Serotyping of Escherichia coli
Ørskov, F., & Ørskov, I. (1984) · Methods in Microbiology · doi:10.1016/s0580-9517(08)70447-1 · Cited by 579
Host-specific fimbrial adhesins of noninvasive enterotoxigenic Escherichia coli strains
Gaastra, W., & de Graaf, F. K. (1982) · Microbiological Reviews · doi:10.1128/mmbr.46.2.129-161.1982 · Cited by 527
Metadata
- Authors
- Evans, D. G., & Evans, D. J.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1978-08
- Volume
- 21
- Issue
- 2
- Pages
- 638-647
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1897547275
- Cited by
- 404
- References
- 0
- FWCI
- 19.84
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: New Surface-Associated Heat-Labile Colonization Factor Antigen (CFA/II) Produced by Enterotoxigenic Escherichia coli of Serogroups O6 and O8. https://app.cochat.ai/papers/10.1128/iai.21.2.638-647.1978
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- Evans, D. G., & Evans, D. J. (1978). New Surface-Associated Heat-Labile Colonization Factor Antigen (CFA/II) Produced by Enterotoxigenic Escherichia coli of Serogroups O6 and O8. Infection and Immunity. https://doi.org/10.1128/iai.21.2.638-647.1978
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