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Macrophages as a source of tumoricidal activity (tumor-necrotizing factor)
Open accessAbstract
Macrophage-enriched peritoneal exudate cells from mice infected with Mycobacterium bovis BCG, macrophage-like tumor cells (PU 5-1.8), and peritoneal macrophages propagated in vitro with macrophage growth factor released tumoricidal activity into the culture medium within 2 to 3 h after stimulation with nanogram quantities of bacterial lipopolysaccharide. The cytotoxic activities from each of the macrophage culture supernatants eluted from diethylaminoethyl-Sephacel columns at a sodium chloride concentration of 200 mM exhibited a molecular weight of 50,000 to 60,000 as estimated by gel filtration, were stable at 56 degrees C for 30 min, and were active at a pH range of 6 to 10. A rabbit antiserum directed against serum-derived cytotoxic activity (tumor-necrotizing factor) from BCG-infected and lipopolysaccharide-challenged mice inhibited all of the cytotoxic activities generated in vitro. This suggests that the macrophage-derived cytotoxins are identical with serum-derived cytotoxic factor, which further implies that the macrophage is the cellular source of tumor-necrotizing factor.
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Citations
Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Cited by
Cachectin and tumour necrosis factor as two sides of the same biological coin
Beutler, B., & Cerami, A. (1986) · Nature · doi:10.1038/320584a0 · Cited by 1,647
Sherry, B., & Cerami, A. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1269 · Cited by 432
ANDUS, T., GEIGER, T., HIRANO, T., KISHIMOTO, T., TRAN‐THI, T., DECKER, K., & HEINRICH, P. C. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb13997.x · Cited by 188
Acute mesenteric ischemia: Pathophysiology, diagnosis, and treatment
Benjamin, E., & Oropello, J. M. (1993) · Disease-a-Month · doi:10.1016/0011-5029(93)90023-v · Cited by 150
Bissonnette, E., & Rola-Pleszczynski, M. (1989) · Inflammation · doi:10.1007/bf00914399 · Cited by 35
Metadata
- Authors
- Männel, D. N., Moore, R. N., & Mergenhagen, S. E.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1980-11
- Volume
- 30
- Issue
- 2
- Pages
- 523-530
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1751790428
- Cited by
- 390
- References
- 1
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Männel, D. N., Moore, R. N., & Mergenhagen, S. E. (1980). Macrophages as a source of tumoricidal activity (tumor-necrotizing factor). Infection and Immunity. https://doi.org/10.1128/iai.30.2.523-530.1980
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
