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Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged
Open accessAbstract
Humoral antibodies and specific cellular immune reactions (proliferative immune response in the lymphocyte transformation test) to varicella-zoster virus antigen were measured in children, young adults, and elderly people. In children and young adults, the humoral varicella-zoster-specific antibodies and the virus-specific cellular immune response generally coincided. In the over-60 age group, however, a discrepancy was often observed between these parameters. Ninety percent of the elderly subjects showed humoral antibodies, but only 64% still had a measurable varicella-zoster-specific immune response. There was no correlation between the magnitude of the virus antigen-specific immune response and the mitogen-induced lymphoproliferative response (phytohemagglutinin stimulation). One in three elderly people, therefore, showed no cellular immune response to the varicella-zoster virus antigen, and this person could probably be regarded as a potential herpes zoster patient.
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Citations
Cited by
A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
Oxman, M. N., Levin, M. J., Johnson, G. R., Schmader, K. E., Straus, S. E., Gelb, L. D., Arbeit, R. D., Simberkoff, M. S., Gershon, A. A., Davis, L. E., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051016 · Cited by 2,412
Arvin, A. M. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.3.361 · Cited by 1,162
Weller, T. H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312013092205 · Cited by 493
Varicella‐Zoster Virus–Specific Immune Responses in Elderly Recipients of a Herpes Zoster Vaccine
Levin, M. J., Oxman, M. N., Zhang, J. H., Johnson, G. R., Stanley, H., Hayward, A. R., Caulfield, M. J., Irwin, M. R., Smith, J. G., Clair, J., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/528696 · Cited by 355
Herpes Zoster and Tofacitinib Therapy in Patients With Rheumatoid Arthritis
Winthrop, K. L., Yamanaka, H., Valdez, H., Mortensen, E., Chew, R., Krishnaswami, S., Kawabata, T., & Riese, R. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38745 · Cited by 353
Metadata
- Authors
- Berger, R., Florent, G., & Just, M.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1981-04
- Volume
- 32
- Issue
- 1
- Pages
- 24-27
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1930140134
- Cited by
- 218
- References
- 0
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Berger, R., Florent, G., & Just, M. (1981). Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged. Infection and Immunity. https://doi.org/10.1128/iai.32.1.24-27.1981
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