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Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells
Open accessAbstract
Human uroepithelial (T24) cells were incubated for 24 h in the presence of various concentrations of human recombinant gamma interferon (Hu-rIFN-gamma) and then infected with the 6BC strain of Chlamydia psittaci. This resulted in a reduction of intracellular chlamydial inclusion development in proportion to the concentration of Hu-rIFN-gamma present when Giemsa-stained cells were examined by light microscopy 24 h after infection. When tryptophan was added to Hu-rIFN-gamma-treated cells just after infection, reversal of the Hu-rIFN-gamma-mediated inhibition occurred in proportion to the concentration of tryptophan added. Addition of either isoleucine or lysine did not result in reversal of the antichlamydial state. Transport of L-[3H]tryptophan into acid-soluble intracellular pools was found to be greatly enhanced in Hu-rIFN-gamma-treated T24 cells compared with the rates measured for untreated cells. Transport of [3H]leucine was not increased in treated cells. Cells treated with Hu-rIFN-gamma also degraded L-[3H]tryptophan to catabolites that cochromatographed with N-formylkynurenine and kynurenine as measured by high-performance liquid chromatography. We conclude that Hu-rIFN-gamma-mediated inhibition of intracellular C. psittaci replication in T24 cells occurs by depletion of the essential amino acid tryptophan, most likely via the induction of indoleamine-2,3-dioxygenase, the initial enzyme of tryptophan catabolism.
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Cited by
Maes, M., Leonard, B. E., Myint, A. M., Kubera, M., & Verkerk, R. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.017 · Cited by 700
Beatty, W. L., Byrne, G. I., & Morrison, R. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.3998 · Cited by 466
Self-citationThomas, S., Izard, J., Walsh, E., Batich, K., Chongsathidkiet, P., Clarke, G., Sela, D. A., Muller, A. J., Mullin, J. M., Albert, K., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2929 · Cited by 367
Byrd, T. F., & Horwitz, M. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114038 · Cited by 320
Morrison, R. P., Belland, R. J., Lyng, K., & Caldwell, H. D. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.4.1271 · Cited by 317
Metadata
- Authors
- Byrne, G. I., Lehmann, L. K., & Landry, G. J.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1986-08
- Volume
- 53
- Issue
- 2
- Pages
- 347-351
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1892959235
- Cited by
- 385
- References
- 0
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells. https://app.cochat.ai/papers/10.1128/iai.53.2.347-351.1986
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- Byrne, G. I., Lehmann, L. K., & Landry, G. J. (1986). Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells. Infection and Immunity. https://doi.org/10.1128/iai.53.2.347-351.1986
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