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Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor
Open accessAbstract
The results of this study show that lipoarabinomannans (LAM) isolated from a virulent strain and from an avirulent strain of Mycobacterium tuberculosis, which have recently been shown to differ markedly in terms of the structures of their nonreducing termini, also differ markedly in the capacity to induce the secretion of tumor necrosis factor from murine macrophages. It was found that LAM from the avirulent H37Ra strain was 100-fold more potent at inducing tumor necrosis factor secretion than LAM from the virulent Erdman strain, thus leading us to hypothesize that the structure of LAM from a given mycobacterial isolate may directly influence its ability to elicit, or avoid, cytokine-mediated mechanisms of host resistance.
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Cited by
Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis
Means, T. K., Wang, S., Lien, E., Yoshimura, A., Golenbock, D. T., & Fenton, M. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3920 · Cited by 804
The Envelope Layers of Mycobacteria with Reference to their Pathogenicity
Daffé, M., & Draper, P. (1997) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60016-8 · Cited by 730
CD14 Is a pattern recognition receptor
Pugin, J., Heumann, D., Tomasz, A., Kravchenko, V. V., Akamatsu, Y., Nishijima, M., Glauser, M. P., Tobias, P. S., & Ulevitch, R. J. (1994) · Immunity · doi:10.1016/1074-7613(94)90093-0 · Cited by 699
Briken, V., Porcelli, S. A., Besra, G. S., & Kremer, L. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04183.x · Cited by 425
Lipoarabinomannans: from structure to biosynthesis
Nigou, J. (2003) · Biochimie · doi:10.1016/s0300-9084(03)00048-8 · Cited by 277
Metadata
- Authors
- Chatterjee, D., Roberts, A. D., Lowell, K., Brennan, P. J., & Orme, I. M.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1992-03
- Volume
- 60
- Issue
- 3
- Pages
- 1249-1253
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2180743237
- Cited by
- 218
- References
- 0
- FWCI
- 18.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Chatterjee, D., Roberts, A. D., Lowell, K., Brennan, P. J., & Orme, I. M. (1992). Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor. Infection and Immunity. https://doi.org/10.1128/iai.60.3.1249-1253.1992
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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