Coordinate regulation of two opaque-phase-specific genes during white-opaque switching in Candida albicans

Morrow, B; Srikantha, T; Anderson, J; Soll, D R

doi:10.1128/iai.61.5.1823-1828.1993

Coordinate regulation of two opaque-phase-specific genes during white-opaque switching in Candida albicans

Cells of Candida albicans WO-1 switch spontaneously and frequently between a white and an opaque CFU. Recently, an opaque-phase-specific cDNA, PEP1, was cloned and was demonstrated to code for a pepsinogen. By using a differential hybridization screen, a second opaque-phase-specific cDNA, Op4, ha…