The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity
Open accessAbstract
Helicobacter pylori is involved in gastritis, gastric and duodenal ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. Earlier studies already suggested a role for autoimmune phenomena in H. pylori-linked disease. We now report that lipopolysaccharides (LPS) of H. pylori express Lewis y, Lewis x, and H type I blood group structures similar to those commonly occurring in gastric mucosa. Immunization of mice and rabbits with H. pylori cells or purified LPS induced an anti-Lewis x or y or anti-H type I response, yielding antibodies that bound human and murine gastric glandular tissue, granulocytes, adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma cells. Experimental oral infections in mice or natural infection in humans yielded anti-Lewis antibodies also. The beta chain of gastric (H+,K+)-ATPase, the parietal cell proton pump involved in acid secretion, contained Lewis y epitopes; gastric mucin contained Lewis x and y antigenic determinants. Growth in mice of a hybridoma that secretes H. pylori-induced anti-Lewis y monoclonal antibodies resulted in histopathological evidence of gastritis, which indicates a direct pathogenic role for anti-Lewis antibodies. In conclusion, our observations demonstrate that molecular mimicry between H. pylori LPS and the host, based on Lewis antigens, and provide understanding of an autoimmune mechanism for H. pylori-associated type B gastritis.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels
Tsai, C.-M., & Frasch, C. E. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90673-x · Cited by 3,067
Helicobacter pylori Infection and Gastric Lymphoma
Parsonnet, J., Hansen, S., Rodriguez, L., Gelb, A. B., Warnke, R. A., Jellum, E., Orentreich, N., Vogelman, J. H., & Friedman, G. D. (1994) · New England Journal of Medicine · doi:10.1056/nejm199405053301803 · Cited by 1,831
Development of a Mouse Model of Helicobacter pylori Infection that Mimics Human Disease
Marchetti, M., Aricò, B., Burroni, D., Figura, N., Rappuoli, R., & Ghiara, P. (1995) · Science · doi:10.1126/science.7886456 · Cited by 562
Self-citationTHE PREVALENCE OF HELICOBACTER PYLORI IN PEPTIC ULCER DISEASE
Pounder, R. E., & Ng, D. (1995) · Cited by 353
Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa
Negrini, R., Lisato, L., Zanella, I., Cavazzini, L., Gullini, S., Villanacci, V., Poiesi, C., Albertini, A., & Ghielmi, S. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90023-e · Cited by 320
Self-citationVelupillai, P., & Harn, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.18 · Cited by 299
The prevalence of Helicobacter pylori in peptic ulcer disease.
Kuipers, E. J., Thijs, J. C., & Festen, H. P. (1995) · PubMed · Cited by 246
Self-citationKarlsson, F. A., Burman, P., Lööf, L., & Mårdh, S. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113344 · Cited by 223
Aspinall, G. O., McDonald, A. G., Pang, H., Kurjanczyk, L. A., & Penner, J. L. (1994) · Biochemistry · doi:10.1021/bi00167a032 · Cited by 210
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Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease
Katz, P. O., Gerson, L. B., & Vela, M. F. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.444 · Cited by 1,767
Falk, P. G., Hooper, L. V., Midtvedt, T., & Gordon, J. I. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1157-1170.1998 · Cited by 657
Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype
Bamford, K. B., Fan, X., Crowe, S. E., Leary, J. F., Gourley, W. K., Luthra, G. K., Brooks, E. G., Graham, D. Y., Reyes, V. E., & Ernst, P. B. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70531-1 · Cited by 573
Ernst, P. B., & Gold, B. D. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.615 · Cited by 554
Epithelial attachment alters the outcome of Helicobacter pylori infection
Guruge, J. L., Falk, P. G., Lorenz, R. G., Dans, M., Wirth, H.-P., Blaser, M. J., Berg, D. E., & Gordon, J. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3925 · Cited by 302
Metadata
- Authors
- Appelmelk, B. J., Simoons-Smit, I., Negrini, R., Moran, A. P., Aspinall, G. O., Forte, J. G., De Vries, T., Quan, H., Verboom, T., Maaskant, J. J., Ghiara, P., Kuipers, E. J., Bloemena, E., Tadema, T. M., Townsend, R. R., Tyagarajan, K., Crothers, J. M., Monteiro, M. A., Savio, A., & De Graaff, J.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1996-06
- Volume
- 64
- Issue
- 6
- Pages
- 2031-2040
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1893832291
- Cited by
- 431
- References
- 25
- FWCI
- 44.17
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Appelmelk, B. J., Simoons-Smit, I., Negrini, R., Moran, A. P., Aspinall, G. O., Forte, J. G., De Vries, T., Quan, H., Verboom, T., Maaskant, J. J., Ghiara, P., Kuipers, E. J., Bloemena, E., Tadema, T. M., Townsend, R. R., Tyagarajan, K., Crothers, J. M., Monteiro, M. A., Savio, A., & De Graaff, J. (1996). Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity. Infection and Immunity. https://doi.org/10.1128/iai.64.6.2031-2040.1996
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
