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Reduced Response to Multiple Vaccines Sharing Common Protein Epitopes That Are Administered Simultaneously to Infants
Open accessAbstract
The plethora of newly discovered vaccines implies that, in the future, many vaccines will have to be administered simultaneously to infants. We examined the potential interference with the immune response of several coadministered vaccines containing the same protein component, namely, tetanus toxoid (TT). Infants simultaneously receiving a tetravalent pneumococcal vaccine conjugated to TT (PncT) and a diphtheria-tetanus-pertussis–poliovirus–Haemophilus influenzae type b-tetanus conjugate vaccine showed significantly lower anti-H. influenzae type b polysaccharide (polyribosylribitol phosphate [PRP]) antibody concentrations than those receiving either a tetravalent pneumococcal vaccine conjugated to diphtheria toxoid or placebo. A dose range study showed that anti-PRP antibody concentrations were inversely related to the TT content of the PncT vaccines administered in infancy. Postimmunization antitetanus antibody concentrations were also affected adversely as the TT content of the coadministered vaccines was increased. This phenomenon, which we believe derives from interference by a common protein carrier, should be taken into account when the introduction of an immunization program including multiple conjugate vaccines is considered.
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References 27 · Cited by 242
Research works printed but not linked: 28
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Metadata
- Authors
- Dagan, R., Eskola, J., Leclerc, C., & Leroy, O.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- <!--label omitted: 3-->National Public Health Institute, Helsinki, Finland3; and
- Institut Pasteur (FR)
- <!--label omitted: 5-->Pasteur Mérieux Connaught, Marnes la Coquette,5 France
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1998-05
- Volume
- 66
- Issue
- 5
- Pages
- 2093-2098
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC108168
- OpenAlex
- W2169803204
- Cited by
- 242
- References
- 27
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 5
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Infection and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- Kela
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Keywords
- vaccine interference, simultaneous vaccination, infants, tetanus toxoid, conjugate vaccines, Haemophilus influenzae type b conjugate vaccine, anti-PrP antibodies, vaccine immunogenicity
- MeSH terms
- Antibodies, Bacterial, Epitopes, Diphtheria Toxoid, Female, Humans, Infant, Male, Pertussis Vaccine, Poliovirus Vaccine, Inactivated, Polysaccharides, Tetanus Toxoid, Diphtheria-Tetanus-Pertussis Vaccine, Vaccines, Combined, Haemophilus Vaccines, Vaccines, Conjugate
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