The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Interleukin 18 Contributes to Host Resistance and Gamma Interferon Production in Mice Infected with Virulent Salmonella typhimurium
Open accessAbstract
Spleen and peritoneal macrophages obtained from innately resistant A/J mice released low levels of interleukin 18 (IL-18) upon infection with Salmonella typhimurium C5 RP4. Incubating the cells with recombinant gamma interferon (rIFN-γ) enhanced IL-18 production. A/J mice treated in vivo with anti-IL-18 antibodies showed impaired resistance to infection, with increased bacterial loads in the liver and spleen. Administration of rIL-18 could protect A/J mice from challenge with a lethal dose of virulent salmonellae, with a dramatic reduction in bacterial numbers in the tissues. rIL-18 administration did not ameliorate the disease in IFN-γ-R−/−mice. IL-18 proved to be required for IFN-γ production by mouse splenocytes from conventional,scid, and rag-1−/−mice; in vivo IL-18 neutralization caused a decrease in circulating IFN-γ levels. Thus, IL-18 is a key factor in early host resistance to Salmonella and probably acts via IFN-γ.
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Richter-Dahlfors, A., Buchan, A. M. J., & Finlay, B. B. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.4.569 · Cited by 502
Lang, T., Prina, E., Sibthorpe, D., & Blackwell, J. M. (1997) · Infection and Immunity · doi:10.1128/iai.65.2.380-386.1997 · Cited by 75
Cited by
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Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,315
Self-citationSalmonella, the host and disease: a brief review
Coburn, B., Grassl, G. A., & Finlay, B. B. (2007) · Immunology & Cell Biology · doi:10.1038/sj.icb.7100007 · Cited by 690
Persistent bacterial infections: the interface of the pathogen and the host immune system
Monack, D. M., Mueller, A., & Falkow, S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro955 · Cited by 572
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Nahid, M. A., Pauley, K. M., Satoh, M., & Chan, E. K. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056317 · Cited by 423
Mastroeni, P., Vazquez-Torres, A., Fang, F. C., Xu, Y., Khan, S., Hormaeche, C. E., & Dougan, G. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.237 · Cited by 399
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Metadata
- Authors
- Mastroeni, P., Clare, S., Khan, S., Harrison, J. A., Hormaeche, C. E., Okamura, H., Kurimoto, M., & Dougan, G.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1999-02
- Volume
- 67
- Issue
- 2
- Pages
- 478-483
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2099872746
- Cited by
- 208
- References
- 2
- FWCI
- 44.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Mastroeni, P., Clare, S., Khan, S., Harrison, J. A., Hormaeche, C. E., Okamura, H., Kurimoto, M., & Dougan, G. (1999). Interleukin 18 Contributes to Host Resistance and Gamma Interferon Production in Mice Infected with Virulent Salmonella typhimurium. Infection and Immunity. https://doi.org/10.1128/iai.67.2.478-483.1999
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