The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Mannose-Binding Lectin Binds to a Range of Clinically Relevant Microorganisms and Promotes Complement Deposition
Open accessAbstract
Mannose-binding lectin (MBL) is a collagenous serum lectin believed to be of importance in innate immunity. Genetically determined low levels of the protein are known to predispose to infections. In this study the binding of purified MBL to pathogens isolated from immunocompromised children was investigated by flow cytometry. Diverse Candida species,Aspergillus fumigatus,Staphylococcus aureus, and beta-hemolytic group A streptococci exhibited strong binding of MBL, whereas Escherichia coli,Klebsiella species, and Haemophilus influenzae type b were characterized by heterogeneous binding patterns. In contrast, beta-hemolytic group B streptococci,Streptococcus pneumoniae, and Staphylococcus epidermidis showed low levels of binding. Bound MBL was able to promote C4 deposition in a concentration-dependent manner. We conclude that MBL may be of importance in first-line immune defense against several important pathogens.
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Cites
Structure of a C-type mannose-binding protein complexed with an oligosaccharide
Weis, W. I., Drickamer, K., & Hendrickson, W. A. (1992) · Nature · doi:10.1038/360127a0 · Cited by 885
A second serine protease associated with mannan-binding lectin that activates complement
Thiel, S., Vorup-Jensen, T., Stover, C. M., Schwaeble, W., Laursen, S. B., Poulsen, K., Willis, A. C., Eggleton, P., Hansen, S., Holmskov, U., et al. (1997) · Nature · doi:10.1038/386506a0 · Cited by 808
Matsushita, M., & Fujita, T. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.6.1497 · Cited by 645
Molecular basis of opsonic defect in immunodeficient children
Sumiya, M., Tabona, P., Arai, T., Summerfield, J. A., Super, M., Levinsky, R. J., & Turner, M. W. (1991) · The Lancet · doi:10.1016/0140-6736(91)93263-9 · Cited by 538
Self-citationEngineering galactose-binding activity into a C-type mannose-binding protein
Drickamer, K. (1992) · Nature · doi:10.1038/360183a0 · Cited by 477
Collectins: collagenous C-type lectins of the innate immune defense system
Holmskov, U., Malhotra, R., Sim, R. B., & Jensenius, J. C. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90136-8 · Cited by 457
The human mannose-binding protein functions as an opsonin.
Kuhlman, M., Joiner, K., & Ezekowitz, R. A. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.5.1733 · Cited by 434
Serum lectin with known structure activates complement through the classical pathway.
Ikeda, K., Sannoh, T., Kawasaki, N., Kawasaki, T., & Yamashina, I. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47587-4 · Cited by 424
Lipscombe, R. J., Sumiya, M., Hill, A. V. S., Lau, Y. L., Levinsky, R. J., Summerfield, J. A., & Turner, M. W. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.9.709 · Cited by 399
Self-citationSummerfield, J. A., Sumiya, M., Levin, M., & Turner, M. W. (1997) · BMJ · doi:10.1136/bmj.314.7089.1229 · Cited by 362
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Cited by
Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis
Dagenais, T. R. T., & Keller, N. P. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00055-08 · Cited by 993
Genetic Dissection of Immunity to Mycobacteria: The Human Model
Casanova, J.-L., & Abel, L. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081501.125851 · Cited by 991
Stevens, D. A., Moss, R. B., Kurup, V. P., Knutsen, A. P., Greenberger, P., Judson, M. A., Denning, D. W., Crameri, R., Brody, A. S., Light, M., et al. (2003) · Clinical Infectious Diseases · doi:10.1086/376525 · Cited by 790
Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense
Holmskov, U., Thiel, S., & Jensenius, J. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140954 · Cited by 762
Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors
Gonçalves, B., Ferreira, C., Alves, C. T., Henriques, M., Azeredo, J., & Silva, S. (2016) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2015.1091805 · Cited by 669
Metadata
- Authors
- Neth, O., Jack, D. L., Dodds, A. W., Holzel, H., Klein, N. J., & Turner, M. W.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2000-02
- Volume
- 68
- Issue
- 2
- Pages
- 688-693
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2171219043
- Cited by
- 561
- References
- 27
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Neth, O., Jack, D. L., Dodds, A. W., Holzel, H., Klein, N. J., & Turner, M. W. (2000). Mannose-Binding Lectin Binds to a Range of Clinically Relevant Microorganisms and Promotes Complement Deposition. Infection and Immunity. https://doi.org/10.1128/iai.68.2.688-693.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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