The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Role of Surface Protein SasG in Biofilm Formation by Staphylococcus aureus
Open accessAbstract
The SasG surface protein of Staphylococcus aureus has been shown to promote the formation of biofilm. SasG comprises an N-terminal A domain and repeated B domains. Here we demonstrate that SasG is involved in the accumulation phase of biofilm, a process that requires a physiological concentration of Zn 2+ . The B domains, but not the A domain, are required. Purified recombinant B domain protein can form dimers in vitro in a Zn 2+ -dependent fashion. Furthermore, the protein can bind to cells that have B domains anchored to their surface and block biofilm formation. The full-length SasG protein exposed on the cell surface is processed within the B domains to a limited degree, resulting in cleaved proteins of various lengths being released into the supernatant. Some of the released molecules associate with the surface-exposed B domains that remain attached to the cell. Studies using inhibitors and mutants failed to identify any protease that could cause the observed cleavage within the B domains. Extensively purified recombinant B domain protein is very labile, and we propose that cleavage occurs spontaneously at labile peptide bonds and that this is necessary for biofilm formation.
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Heilmann, C., Hussain, M., Peters, G., & Götz, F. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.4101774.x · Cited by 700
Conrady, D. G., Brescia, C. C., Horii, K., Weiss, A. A., Hassett, D. J., & Herr, A. B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807717105 · Cited by 216
Cited by
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3161 · Cited by 1,533
Self-citationArciola, C. R., Campoccia, D., Speziale, P., Montanaro, L., & Costerton, J. W. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.031 · Cited by 1,047
Self-citationHobley, L., Harkins, C., MacPhee, C. E., & Stanley-Wall, N. R. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv015 · Cited by 581
“A common theme is that lack of insight of the CWA protein ligands is limiting our understanding of their function.”
BackgroundInfluentialMethicillin resistance and the biofilm phenotype in Staphylococcus aureus
McCarthy, H., Rudkin, J. K., Black, N. S., Gallagher, L., O'Neill, E., & O'Gara, J. P. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00001 · Cited by 426
Self-citationPozzi, C., Waters, E. M., Rudkin, J. K., Schaeffer, C. R., Lohan, A. J., Tong, P., Loftus, B. J., Pier, G. B., Fey, P. D., Massey, R. C., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002626 · Cited by 294
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Metadata
- Authors
- Geoghegan, J. A., Corrigan, R. M., Gruszka, D. T., Speziale, P., O'Gara, J. P., Potts, J. R., & Foster, T. J.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2010-11
- Volume
- 192
- Issue
- 21
- Pages
- 5663-5673
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2126828161
- Cited by
- 213
- References
- 2
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Geoghegan, J. A., Corrigan, R. M., Gruszka, D. T., Speziale, P., O'Gara, J. P., Potts, J. R., & Foster, T. J. (2010). Role of Surface Protein SasG in Biofilm Formation by Staphylococcus aureus. Journal of Bacteriology. https://doi.org/10.1128/jb.00628-10
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