Cited by 273Antimicrobial Resistance in StaphylococcusBacterial Genetics and BiotechnologyEvolution and Genetic Dynamics

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Complete and SOS-Mediated Response of Staphylococcus aureus to the Antibiotic Ciprofloxacin

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Cirz, Ryan T., Jones, Marcus B., Gingles, Neill A., Minogue, Timothy D., Jarrahi, Behnam, Peterson, Scott N., Romesberg, Floyd E.·2007·Journal of Bacteriology

DOI 10.1128/jb.01464-06PMC PMC1797410

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Abstract

Staphylococcus aureus infections can be difficult to treat due to both multidrug resistance and the organism's remarkable ability to persist in the host. Persistence and the evolution of resistance may be related to several complex regulatory networks, such as the SOS response, which modifies transcription in response to environmental stress. To understand how S. aureus persists during antibiotic therapy and eventually emerges resistant, we characterized its global transcriptional response to ciprofloxacin. We found that ciprofloxacin induces prophage mobilization as well as significant alterations in metabolism, most notably the up-regulation of the tricarboxylic acid cycle. In addition, we found that ciprofloxacin induces the SOS response, which we show, by comparison of a wild-type strain and a non-SOS-inducible lexA mutant strain, includes the derepression of 16 genes. While the SOS response of S. aureus is much more limited than those of Escherichia coli and Bacillus subtilis , it is similar to that of Pseudomonas aeruginosa and includes RecA, LexA, several hypothetical proteins, and a likely error-prone Y family polymerase whose homologs in other bacteria are required for induced mutation. We also examined induced mutation and found that either the inability to derepress the SOS response or the lack of the LexA-regulated polymerase renders S. aureus unable to evolve antibiotic resistance in vitro in response to UV damage. The data suggest that up-regulation of the tricarboxylic acid cycle and induced mutation facilitate S. aureus persistence and evolution of resistance during antibiotic therapy.

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Drlica, K., & Zhao, X. (1997) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.61.3.377-392.1997 · Cited by 1,272
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Lorenz, M. C., & Fink, G. R. (2001) · Nature · doi:10.1038/35083594 · Cited by 745
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Miller, C., Thomsen, L. E., Gaggero, C., Mosseri, R., Ingmer, H., & Cohen, S. N. (2004) · Science · doi:10.1126/science.1101630 · Cited by 584
Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance
Cirz, R. T., Chin, J. K., Andes, D. R., de Crécy‐Lagard, V., Craig, W. A., & Romesberg, F. E. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030176 · Cited by 583
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Wan, L., Liu, M., Oikonomou, P., Blattman, S. B., Berisa, M., Paul, F., Hettleman, J., Gonzalez, J., Hu, Q., Chen, H., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeb9875 · Cited by 5
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Huber, C., Wolf, S. A., Ziebuhr, W., Holmes, M. A., Assmann, J., Lübke‐Becker, A., Thürmer, A., Semmler, T., Brombach, J., Bethe, A., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.969961 · Cited by 5
Structure, function and evolution of the bacterial DinG-like proteins
Cheng, K. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.03.023 · Cited by 5
Clindamycin Protects Nonhuman Primates Against Inhalational Anthrax But Does Not Enhance Reduction of Circulating Toxin Levels When Combined With Ciprofloxacin
Vietri, N. J., Tobery, S. A., Chabot, D. J., Ingavale, S. S., Somerville, B., Miller, J. A., Schellhase, C. W., Twenhafel, N. A., Fetterer, D. P., Cote, C. K., et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa365 · Cited by 5
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The Mechanisms of Action and Resistance to Fluoroquinolone in Helicobacter pylori Infection
Negrei, C., & Bo, D. (2014) · InTech eBooks · doi:10.5772/57081 · Cited by 9
Exploiting the Achilles’ Heel of Iron Dependence in Antibiotic Resistant Bacteria with New Antimicrobial Iron Withdrawal Agents
Holbein, B. E., Ang, M. T. C., Allan, D. S., Chen, W., & Lehmann, C. (2021) · Sustainable agriculture reviews · doi:10.1007/978-3-030-58259-3_8 · Cited by 5
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References
(2020) · Wiley eBooks · doi:10.1002/9781119309697.ref
Stress responses and survival strategies in the opportunistic pathogen Acinetobacter baumannii
Ching, C. (2018) · doi:10.17760/d20316296
ATP-dependent restriction enzyme SauUSI from Staphylococcus aureus is also a bona fide single strand DNA endonucleasePreprint
Tumuluri, V. S., & Saikrishnan, K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.11.519956
Molecular recognition of anion binding proteins: Characterization and inhibition
Schuurs, Z. P. (2023) · Queensland University of Technology · doi:10.5204/thesis.eprints.246091
The host environment rather than biofilm growth activates stress responses and conveys ciprofloxacin tolerance in Staphylococcus aureusPreprint
Petersen, M. E., Khamas, A. B., Meltofte, C. A., Mikkelsen, F. C., Hundevadt, E. I. B., Hoppe, M. E., Wood, T. K., & Meyer, R. L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.07.669083
Additional file 2 of Flexible comparative genomics of prokaryotic transcriptional regulatory networks
Kılıç, S., Sánchez−Osuna, M., Collado-Padilla, A., Barbé, J., & Erill, I. (2020) · Figshare · doi:10.6084/m9.figshare.13467969
Additional file 1 of Delving into the lifestyle of Sundarban Wetland resident, biofilm producing, halotolerant Salinicoccus roseus: a comparative genomics-based intervention
Dutta, B., Halder, U., Chitikineni, A., Varshney, R. K., & Bandopadhyay, R. (2024) · Figshare · doi:10.6084/m9.figshare.26639028
Additional file 1 of Flexible comparative genomics of prokaryotic transcriptional regulatory networks
Kılıç, S., Sánchez−Osuna, M., Collado-Padilla, A., Barbé, J., & Erill, I. (2020) · Figshare · doi:10.6084/m9.figshare.13467965
Additional file 3 of Flexible comparative genomics of prokaryotic transcriptional regulatory networks
Kılıç, S., Sánchez−Osuna, M., Collado-Padilla, A., Barbé, J., & Erill, I. (2020) · Figshare · doi:10.6084/m9.figshare.13467971
Staphylococcus aureus se met transitoirement en dormance pour utiliser les acides gras de l'hôte et echapper a une inhibition par un anti-FASII : quel signal active son reveil ?
Kénanian, G. (2018) · theses.fr (ABES) · doi:10.70675/fe7b0135z47bcz47eazb0adz82aa1f9208fd
Staphylococcus aureus Regulatory RNAs Driving Fitness upon Antibiotic Exposure
Liu, W. (2018) · theses.fr (ABES) · doi:10.70675/1ab43e4bz428bz410ez90c9z8b5f463c1e38
Études intégratives de l'ADN gyrase des Corynebacteriales
Yab, E. (2023) · doi:10.70675/976cf0f8z9848z4056za15fz903e5f5c505f
A phage repressor involved in the DNA-damage response of Francisella
Pérez−Varela, M., Sánchez−Osuna, M., Campoy, S., Aranda, J., Barbé, J., & Erill, I. (2026) · PNAS Nexus · doi:10.1093/pnasnexus/pgag114
Photochemical modification of two fluorene-based molecules with DNA intercalating and anti-methicillin resistant Staphylococcus aureus activity
Gaudreau, A., Beckner, M. D., Shen, C., Du, V., Flannagan, R. S., Balaji, V., Papalambropoulos, E., El-Halfawy, O. M., Gillies, E. R., & Heinrichs, D. E. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113133
Antibiotic exposure and recovery of persister states influence virulence phenotypes in Pseudomonas aeruginosa
Nizer, W. S. D. C., Igídio, C. E. D., Ribeiro, E. M., Andrade, A. C. O., de Oliveira, S. N., Teixeira, M. M., Souza, D. G., & Fagundes, C. T. (2026) · Archives of Microbiology · doi:10.1007/s00203-026-04995-3
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Brennan, S., Kaur, I., Spencer, D. L., Purves, J., Sampson, H. R., Ketley, J. M., Geoghegan, J., Andrew, P. W., Waldron, K. J., & Morrissey, J. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.18.732922
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Fong, P.-M., Weaver, A. I., Manson, A. L., Park, Y., Earl, A. M., & Walker, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.23.733835
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Haider, D., Barbakadze, S., Mosler, J. P., Mauerer, S., Read, C., Sendi, P., Conrads, G., & Spellerberg, B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.24.740447
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Antczak, N. M., Ippoliti, P. J., Ahn, J., Kankanamge, L. S. P., Dudko, T., Balfour‐Jeffrey, K., Pancoe, B., MacDiarmid, Z., Pham, C. M., David, W., et al. (2026) · Environmental and Molecular Mutagenesis · doi:10.1002/em.70075
Listeria monocytogenes growth limits and stress resistance mechanisms
van der Veen, S. (2008) · doi:10.18174/122074

Authors: Cirz, R. T., Jones, M. B., Gingles, N. A., Minogue, T. D., Jarrahi, B., Peterson, S. N., & Romesberg, F. E.
Affiliations: Scripps Research Institute (US)
Pathogen Functional Genomics Resource Center (PFGRC), The Institute for Genomic Research, Rockville, Maryland 20850
Corresponding author: Romesberg, Floyd E.
ORCID: Cirz, Ryan T.
Jones, Marcus B.
Minogue, Timothy D.
Romesberg, Floyd E.
Venue: Journal of Bacteriology
Publisher: American Society for Microbiology
Published: 2007-01-15
Volume: 189
Issue: 2
Pages: 531-539
ISSN: 0021-9193 (ISSN-L)
1098-5530
DOI: 10.1128/jb.01464-06
PMC: PMC1797410
OpenAlex: W1991848397
Cited by: 273
References: 46
Citations by year: 2026: 11 · 2025: 13 · 2024: 22 · 2023: 15 · 2022: 14 · 2021: 20 · 2020: 19 · 2019: 14 · 2018: 13 · 2017: 8 · 2016: 12 · 2015: 11 · 2014: 10 · 2013: 16 · 2012: 17
FWCI: 6.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Bacteriology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01ai15447-36-0-3)
Office of Naval Research
National Institute of Allergy and Infectious Diseases (N01 AI015447)
Topics: Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: Staphylococcus aureus, ciprofloxacin, SOS response, antibiotic resistance, bacterial persistence, TCA cycle, LexA, RecA, induced mutation, UV damage
MeSH terms: Anti-Bacterial Agents, Bacterial Proteins, Ciprofloxacin, Citric Acid Cycle, Mutation, SOS Response, Genetics, Staphylococcus aureus, Ultraviolet Rays, Gene Expression Regulation, Bacterial, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Drug Resistance, Bacterial

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Complete and SOS-Mediated Response of Staphylococcus aureus to the Antibiotic Ciprofloxacin

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