The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Inverse Regulation of Biofilm Formation and Swarming Motility by Pseudomonas aeruginosa PA14
Open accessAbstract
We previously reported that SadB, a protein of unknown function, is required for an early step in biofilm formation by the opportunistic pathogen Pseudomonas aeruginosa. Here we report that a mutation in sadB also results in increased swarming compared to the wild-type strain. Our data are consistent with a model in which SadB inversely regulates biofilm formation and swarming motility via its ability both to modulate flagellar reversals in a viscosity-dependent fashion and to influence the production of the Pel exopolysaccharide. We also show that SadB is required to properly modulate flagellar reversal rates via chemotaxis cluster IV (CheIV cluster). Mutational analyses of two components of the CheIV cluster, the methyl-accepting chemotaxis protein PilJ and the PilJ demethylase ChpB, support a model wherein this chemotaxis cluster participates in the inverse regulation of biofilm formation and swarming motility. Epistasis analysis indicates that SadB functions upstream of the CheIV cluster. We propose that P. aeruginosa utilizes a SadB-dependent, chemotaxis-like regulatory pathway to inversely regulate two key surface behaviors, biofilm formation and swarming motility.
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1 retracted
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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
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Microbial Biofilms: from Ecology to Molecular Genetics
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Self-citationFlagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
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Pseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm
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“Microscopic observations (23, 26, 40, 51) and genetic analyses (2) revealed two sequential events that lead to stable surface interactions.”
BackgroundCommon Virulence Factors for Bacterial Pathogenicity in Plants and Animals
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Cited by
Pseudomonas aeruginosa: all roads lead to resistance
Breidenstein, E. B. M., de la Fuente-Núñez, C., & Hancock, R. E. W. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.04.005 · Cited by 1,286
Microtiter Dish Biofilm Formation Assay
O'Toole, G. A. (2011) · Journal of Visualized Experiments · doi:10.3791/2437 · Cited by 1,108
Self-citationSignals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms
Karatan, E., & Watnick, P. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00041-08 · Cited by 1,048
Tuson, H. H., & Weibel, D. B. (2013) · Soft Matter · doi:10.1039/c3sm27705d · Cited by 720
Medically important bacterial-fungal interactions
Peleg, A. Y., Hogan, D. A., & Mylonakis, E. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2313 · Cited by 619
Metadata
- Authors
- Caiazza, N. C., Merritt, J. H., Brothers, K. M., & O'Toole, G. A.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2007-05
- Volume
- 189
- Issue
- 9
- Pages
- 3603-3612
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2143697390
- Cited by
- 288
- References
- 50
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Caiazza, N. C., Merritt, J. H., Brothers, K. M., & O'Toole, G. A. (2007). Inverse Regulation of Biofilm Formation and Swarming Motility by Pseudomonas aeruginosa PA14. Journal of Bacteriology. https://doi.org/10.1128/jb.01685-06
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
