UGA Nonsense Mutations in Salmonella typhimurium
Open accessAbstract
Salmonella typhimurium strain LT-2 carries a weak UGA suppressor activity. This activity prevents the detection of some UGA mutants as auxotrophs and probably accounts for the rarity of his UGA mutants in this strain. A selection method is described which permits the isolation of these rare his UGA mutants. Map distribution of his UGA mutations is normal, and their polarity effects are indistinguishable from the polarity effects of amber and ochre mutations at similar locations. Isolation and properties of a prototrophic his UGA mutant are described. UGA mutants are common among lac mutants isolated from Salmonella strains carrying an F′ lac episome. Apparently the suppressor activity is insufficient to prevent detection of lac UGA mutants. It is not yet clear whether the suppressor activity plays an important role in normal cell physiology.
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UGA is the leakiest of the three stop codons, with a readthrough frequency of at least 10−2 to 10−3 in Salmonella typhimurium and E. coli.
“UGA is the leakiest of the three, with a readthrough frequency of at least 10−2 to 10−3 in Salmonella typhimurium [66] and E. coli {XE “E. coli”} [67,68].”
From Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines (2021) · cites this paper as [66]
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- Authors
- Roth, J. R.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Roth, John R.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1970-05
- Volume
- 102
- Issue
- 2
- Pages
- 467-475
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC247572
- OpenAlex
- W2009554558
- Cited by
- 84
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 7 · 2016: 2 · 2015: 1 · 2012: 1
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Bacteriology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- Salmonella typhimurium, histidine auxotrophy, lac operon, mutation mapping, polarity effect
- MeSH terms
- Chromosome Mapping, Culture Media, Galactosidases, Genetic Code, Genetics, Microbial, Histidine, Mutation, Penicillins, Phosphoric Monoester Hydrolases, Recombination, Genetic, Salmonella Phages, Salmonella typhimurium, Selection, Genetic, Suppression, Genetic, Transduction, Genetic
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