Effects of beta-pinene on yeast membrane functions
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The effects of beta-pinene on yeast cells were studied. This terpene inhibited respiration with glucose or ethanol as the substrate. The inhibition depended on the ratio of the terpene to the amount of yeast cells; for a fixed concentration of pinene, inhibition decreased as the amount of yeast cells increased. Pinene also inhibited the pumping of protons and K+ transport, but this inhibition was more marked with with ethanol than with glucose as the substrate, indicating the mitochondrial localization of the inhibition. The studies on isolated mitochondria showed a series of effects, starting with the disappearance of the respiratory control and deenergization of the organelles and followed by an inhibition of respiration at higher concentrations of the terpene. The effect on respiration could be localized to the cytochrome b region of the electron transport chain. No effect could be detected on the activity of ATPase. The effects can be ascribed to a localization of pinene on membranes which was also accompanied by a decrease in the fluorescence polarization of diphenyl hexatriene, probably meaning an increase in the fluidity of the membrane, localized preferentially to the mitochondria.
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Toxic effects on membrane structure and function are generally used to explain the antimicrobial activity of essential oils.
“Toxic effects on membrane structure and function are generally used to explain the antimicrobial activity of EOs [61,62,63].”
From Effect of essential oils on pathogenic bacteria (2013) · cites this paper as [62]
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References 16 · Cited by 255
- Authors
- Uribe, S., Ramirez, J., & Peña, A.
- ORCID
- Peña, A
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1985-03
- Volume
- 161
- Issue
- 3
- Pages
- 1195-1200
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC215026
- OpenAlex
- W1587535910
- Cited by
- 255
- References
- 16
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 7 · 2019: 5 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 15 · 2014: 14 · 2013: 15 · 2012: 17
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Bacteriology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- β-pinene, terpenes, yeast, Saccharomyces cerevisiae, mitochondrial respiration inhibition, electron transport chain, cytochrome b, membrane fluidity, proton transport, potassium transport, respiratory control, ATPase
- MeSH terms
- Bicyclic Monoterpenes, Adenosine Triphosphatases, Bridged Bicyclo Compounds, Bridged-Ring Compounds, Cell Membrane, Fluorescence Polarization, Hydrogen-Ion Concentration, Intracellular Membranes, Membrane Potentials, Mitochondria, Oxygen Consumption, Potassium, Saccharomyces cerevisiae, Monoterpenes
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