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Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillin-resistant S. aureus-specific penicillin-binding protein
Open accessAbstract
A beta-lactam-sensitive strain of Staphylococcus aureus could be converted to methicillin resistance by the introduction of a plasmid carrying the 4.3-kilobase HindIII chromosomal DNA fragment which encoded the mecA gene from a methicillin-resistant S. aureus. Transformant cells produced methicillin-resistant S. aureus-specific penicillin-binding protein constitutively, and additional insertion of an inducible penicillinase plasmid caused production of the pencillin-binding protein to become inducible.
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Citations
Cited by
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,637
Coagulase-Negative Staphylococci
Becker, K., Heilmann, C., & Peters, G. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00109-13 · Cited by 1,628
Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects
Uddin, T. M., Chakraborty, A. J., Khusro, A., Zidan, B. R. M., Mitra, S., Emran, T. B., Dhama, K., Ripon, M. K. H., Gajdács, M., Sahibzada, M. U. K., et al. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.10.020 · Cited by 1,311
Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials
Bikard, D., Euler, C. W., Jiang, W., Nussenzweig, P. M., Goldberg, G. W., Duportet, X., Fischetti, V. A., & Marraffini, L. A. (2014) · Nature Biotechnology · doi:10.1038/nbt.3043 · Cited by 986
Oliveira, D. C., Tomasz, A., & de Lencastre, H. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00227-x · Cited by 494
Metadata
- Authors
- Ubukata, K., Nonoguchi, R., Matsuhashi, M., & Konno, M.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1989-05
- Volume
- 171
- Issue
- 5
- Pages
- 2882-2885
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1864055940
- Cited by
- 247
- References
- 0
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillin-resistant S. aureus-specific penicillin-binding protein. https://app.cochat.ai/papers/10.1128/jb.171.5.2882-2885.1989
- The paper
- Ubukata, K., Nonoguchi, R., Matsuhashi, M., & Konno, M. (1989). Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillin-resistant S. aureus-specific penicillin-binding protein. Journal of Bacteriology. https://doi.org/10.1128/jb.171.5.2882-2885.1989
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