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The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147
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Plasmid pIP816 of Enterococcus faecium BM4147 confers inducible resistance to vancomycin and encodes the VanH dehydrogenase and the VanA ligase for synthesis of depsipeptide-containing peptidoglycan precursors which bind the antibiotic with reduced affinity. We have characterized a cluster of five genes of pIP816 sufficient for peptidoglycan synthesis in the presence of vancomycin. The distal part of the van cluster encodes VanH, VanA, and a third enzyme, VanX, all of which are necessary for resistance. Synthesis of these enzymes was regulated at the transcriptional level by the VanS-VanR two-component regulatory system encoded by the proximal part of the cluster. VanR was a transcriptional activator related to response regulators of the OmpR subclass. VanS stimulated VanR-dependent transcription and was related to membrane-associated histidine protein kinases which control the level of phosphorylation of response regulators. Analysis of transcriptional fusions with a reporter gene and RNA mapping indicated that the VanR-VanS two-component regulatory system activates a promoter used for cotranscription of the vanH, vanA, and vanX resistance genes.
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“This initial step results in an ATP-dependent phosphorylation of the response regulator VanR, which subsequently binds to two promoters, one of them located upstream of its own gene (vanR) and the other upstream of vanH in Tn1546 (78).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [78]
Citations
Cites
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
[2] New M13 vectors for cloning
Messing, J. W. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)01005-8 · Cited by 5,240
Rapid and sensitive protein similarity searches
Lipman, D. J., & Pearson, W. R. (1985) · Science · doi:10.1126/science.2983426 · Cited by 4,033
Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis
Norrander, J. M., Kempe, T., & Messing, J. W. (1983) · Gene · doi:10.1016/0378-1119(83)90040-9 · Cited by 2,441
Protein phosphorylation and regulation of adaptive responses in bacteria
Stock, J., Ninfa, A. J., & Stock, A. (1989) · Microbiological Reviews · doi:10.1128/mr.53.4.450-490.1989 · Cited by 1,692
Plasmid-Mediated Resistance to Vancomycin and Teicoplanin in Enterococcus Faecium
Leclercq, R., Derlot, E., Duval, J., & Courvalin, P. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807213190307 · Cited by 1,411
Self-citationThe Molecular Basis of Antibiotic Action
Gale, E. F. (1981) · Medical Entomology and Zoology · Cited by 1,217
An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics.
Steers, E., Foltz, E. L., & GRAVES, B. S. (1959) · PubMed · Cited by 1,070
[57] Chloramphenicol acetyltransferase from chloramphenicol-resistant bacteria
Shaw, W. V. (1975) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(75)43141-x · Cited by 804
Nucleotide sequences that signal the initiation of transcription and translation inBacillus subtilis
Moran, C. P., Lang, N., LeGrice, S. F. J., Lee, G. S., Stephens, M., Sonenshein, A. L., Pero, J. G., & Losick, R. M. (1982) · Molecular and General Genetics MGG · doi:10.1007/bf00729452 · Cited by 786
Research works printed but not linked: 1
- Ausubel F. M. R. Brent R. E. Kingston D. D. Moore J. G. Seidman J. A. Smith and K. Struhl. 1987. Current protocols in molecular biology. John Wiley & Sons Inc. New York.
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Self-citationKwun, M. J., Novotna, G. B., Hesketh, A. R., Hill, L. M., & Hong, H. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00523-13 · Cited by 49
Park, I., Lin, C., & Walsh, C. T. (1996) · Biochemistry · doi:10.1021/bi9603128 · Cited by 49
Escobar, I. E., White, A., Kim, W., & Mylonakis, E. E. (2020) · Antibiotics · doi:10.3390/antibiotics9100665 · Cited by 48
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LAI, M. H., & Kirsch, D. R. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.7.1645 · Cited by 47
Fujita, N., Yoshimura, M., Komori, T., Tanimoto, K., & Ike, Y. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.8.2150 · Cited by 46
Wu, Z., & Walsh, C. T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11603 · Cited by 45
Mills, E. G., Sullivan, E., & Kovač, J. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.02302-21 · Cited by 47
Hanrahan, J., Hoyen, C. K., & Rice, L. B. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.5.1349-1351.2000 · Cited by 44
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Malathum, K., & Murray, B. E. (1999) · Drug Resistance Updates · doi:10.1054/drup.1999.0098 · Cited by 44
Hughes, C. S., Longo, E., Phillips‐Jones, M. K., & Hussain, R. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.05.011 · Cited by 42
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Hilbert, F., del Portillo, F. G., & Groisman, E. A. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.7.2158-2165.1999 · Cited by 43
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Milewski, W. M., Boyle‐Vavra, S., Moreira, B. M., Ebert, C. C., & Daum, R. S. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.1.166 · Cited by 42
Billot-Klein, D., Legrand, R., Schoot, B. M., van HEIJENOORT, J., & Gutmann, L. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.19.6208-6212.1997 · Cited by 41
Ren, C., Xu, Q., Mathieu, J., Alvarez, P. J. J., Zhu, L., & Zhao, H. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c03919 · Cited by 41
Phillips‐Jones, M. K., & Harding, S. E. (2018) · Biophysical Reviews · doi:10.1007/s12551-018-0404-9 · Cited by 42
Receptor domains of two-component signal transduction systems
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Hill, C. M., Krause, K. M., Lewis, S. R., Blais, J., Benton, B. M., Mammen, M., Humphrey, P. P. A., Kinana, A. D., & Janc, J. W. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01737-09 · Cited by 41
Lessard, I. A. D., & Walsh, C. T. (1999) · Chemistry & Biology · doi:10.1016/s1074-5521(99)89009-7 · Cited by 42
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Gao, Y. (2001) · Natural Product Reports · doi:10.1039/b100912p · Cited by 40
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Depardieu, F., Foucault, M.-L., Bell, J. M., Dubouix, A., Guibert, M., Lavigne, J., Levast, M., & Courvalin, P. M. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01348-08 · Cited by 38
Self-citationVancomycin-resistant enterococci: Troublemaker of the 21st century
Ranotkar, S., Kumar, P., Zutshi, S., Prashanth, K. S., Bezbaruah, B. K., Anand, J. R., & Lahkar, M. (2014) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2014.04.002 · Cited by 39
O′Brien, D. P., Entress, R. M. H., Cooper, M. A., O’Brien, S. W., Hopkinson, A., & Williams, D. H. (1999) · Journal of the American Chemical Society · doi:10.1021/ja9839769 · Cited by 38
Enzyme level of enterococcal F 1 Fo‐ATPase is regulated by pH at the step of assembly
Arikado, E., Ishihara, H., Ehara, T., Shibata, C., Saito, H., Kakegawa, T., Igarashi, K., & Kobayashi, H. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00031.x · Cited by 37
Healy, V. L., Park, I., & Walsh, C. T. (1998) · Chemistry & Biology · doi:10.1016/s1074-5521(98)90633-0 · Cited by 37
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Petrich, A., Luinstra, K., Groves, D., Chernesky, M., & Mahony, J. B. (1999) · Molecular and Cellular Probes · doi:10.1006/mcpr.1999.0250 · Cited by 36
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Novotna, G. B., Hill, C. H., Vincent, K., Liu, C., & Hong, H. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05869-11 · Cited by 34
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Ozawa, Y., Tanimoto, K., Nomura, T., Yoshinaga, M., Arakawa, Y., & Ike, Y. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.12.6457-6461.2002 · Cited by 33
Induction of vancomycin resistance in Enterococcus faecium by non-glycopeptide antibiotics
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Rational Approaches to Antibacterial Discovery: Pre-Genomic Directed and Phenotypic Screening
Silver, L. L. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1400-1_2 · Cited by 32
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Self-citationMani, N., SANCHET, P., Jiang, Z., McNaney, C. A., DeCenzo, M. T., KNIGHTI, B., STANKIS, M., Kuranda, M., & ROTHSTEIN, D. M. (1998) · The Journal of Antibiotics · doi:10.7164/antibiotics.51.471 · Cited by 32
Casadewall, B., Reynolds, P. E., & Courvalin, P. M. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.11.3436-3446.2001 · Cited by 32
Self-citationPang, S., Boan, P., Lee, T., Gangatharan, S. A., Tan, S. J., Daley, D. A., Lee, Y. T., & Coombs, G. W. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.10.012 · Cited by 31
Torres‐Viera, C., Tsiodras, S., Gold, H. S., Coakley, E. P. G., Wennersten, C. B., Eliopoulos, G. M., Moellering, R. C., & Inouye, R. T. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.3.973-975.2001 · Cited by 31
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Boyle‐Vavra, S., DeJonge, B. L. M., Ebert, C. C., & Daum, R. S. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.21.6756-6763.1997 · Cited by 29
Nomura, T., Tanimoto, K., Shibayama, K., Arakawa, Y., Fujimoto, S., Ike, Y., & Tomita, H. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00747-12 · Cited by 28
Thecmegene ofClostridium difficileconfers multidrug resistance inEnterococcus faecalis
Lebel, S., Bouttier, S., & Lambert, T. (2004) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2004.tb09742.x · Cited by 28
Metadata
- Authors
- Arthur, M., Molinas, C., & Courvalin, P.
- Affiliations
- Institut Pasteur (FR)
- ORCID
- Arthur, M
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1992-04
- Volume
- 174
- Issue
- 8
- Pages
- 2582-2591
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC205897
- OpenAlex
- W1628177336
- Cited by
- 338
- References
- 49
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 4 · 2023: 7 · 2022: 12 · 2021: 11 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 11 · 2015: 4 · 2014: 15 · 2013: 5 · 2012: 4
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Bacteriology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Keywords
- vancomycin resistance, VanX, peptidoglycan biosynthesis, transcriptional regulation, response regulator, histidine kinase, antibiotic resistance genes
- MeSH terms
- Amino Acid Sequence, Bacterial Proteins, Base Sequence, Cloning, Molecular, DNA Mutational Analysis, DNA, Bacterial, Drug Resistance, Microbial, Genes, Bacterial, Genes, Regulator, Molecular Sequence Data, Oligodeoxyribonucleotides, Peptidoglycan, Promoter Regions, Genetic, Protein Kinases, Transcription Factors, Transcription, Genetic, Vancomycin, Polymerase Chain Reaction, Sequence Alignment, Enterococcus faecium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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