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Guanine nucleotide-dependent assembly of FtsZ into filaments
Open accessAbstract
FtsZ is an essential cell division protein that is localized to the leading edge of the bacterial septum in a cytokinetic ring. It contains the tubulin signature motif and is a GTP binding protein with a GTPase activity. Further comparison of FtsZ with eukaryotic tubulins revealed some additional sequence similarities, perhaps indicating a similar GTP binding site. Examination of FtsZ incubated in vitro by electron microscopy revealed a guanine nucleotide-dependent assembly into protein filaments, supporting the hypothesis that the FtsZ ring is formed through self-assembly. FtsZ3, which is unable to bind GTP, does not polymerize, whereas FtsZ2, which binds GTP but is deficient in GTP hydrolysis, is capable of polymerization.
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Cites
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Cited by
Cabeen, M. T., & Jacobs-Wagner, C. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1205 · Cited by 494
Erickson, H. P., Taylor, D. W., Taylor, K. A., & Bramhill, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.519 · Cited by 459
Karimova, G., Dautin, N., & Ladant, D. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.7.2233-2243.2005 · Cited by 455
Ma, X., Ehrhardt, D. W., & Margolin, W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.12998 · Cited by 444
Bacterial Growth and Cell Division: a Mycobacterial Perspective
Hett, E. C., & Rubin, E. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00028-07 · Cited by 408
Metadata
- Authors
- Mukherjee, A., & Lutkenhaus, J.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1994-05
- Volume
- 176
- Issue
- 9
- Pages
- 2754-2758
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2114750851
- Cited by
- 379
- References
- 1
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Mukherjee, A., & Lutkenhaus, J. (1994). Guanine nucleotide-dependent assembly of FtsZ into filaments. Journal of Bacteriology. https://doi.org/10.1128/jb.176.9.2754-2758.1994
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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