The DOI matches its Crossref record.
MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli
Open accessAbstract
The Escherichia coli gene murZ was recently shown to encode UDP-N-acetylglucosamine enolpyruvyl transferase, which catalyzes the first committed step of peptidoglycan biosynthesis (J. L. Marquardt, D. A. Siegele, R. Kolter, and C. T. Walsh, J. Bacteriol. 174:5748-5752, 1992). The map position of murZ (69.3 min) differed from that determined for murA (90 min), a gene which had been previously proposed to encode the same activity (P.S. Venkateswaran and H. C. Wu, J. Bacteriol. 110:935-944, 1972). Here we describe the construction of a chromosomal deletion of murZ and a plasmid containing murZ under arabinose control. Growth of cells containing the murZ deletion was dependent on the expression of murZ from the plasmid. We conclude that murZ is an essential gene and encodes the sole UDP-N-acetylglucosamine enolpyruvyl transferase of E. coli. To simplify the nomenclature, we recommend that murA be used to designate the gene at 69.3 min that encodes this activity and that the designation murZ be abandoned.
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Cited by
Link, A. J., Phillips, D., & Church, G. M. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.20.6228-6237.1997 · Cited by 874
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Domínguez-Escobar, J., Chastanet, A., Crevenna, A. H., Fromion, V., Wedlich-Söldner, R., & Carballido-López, R. (2011) · Science · doi:10.1126/science.1203466 · Cited by 538
Lanie, J. A., Ng, W.-L., Kazmierczak, K. M., Andrzejewski, T. M., Davidsen, T. M., Wayne, K. J., Tettelin, H., Glass, J. I., & Winkler, M. E. (2007) · Journal of Bacteriology · doi:10.1128/jb.01148-06 · Cited by 443
Recent advances in the formation of the bacterial peptidoglycan monomer unit (1985 to 2000)
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Metadata
- Authors
- Brown, E. D., Vivas, E. I., Walsh, C. T., & Kolter, R.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1995-07
- Volume
- 177
- Issue
- 14
- Pages
- 4194-4197
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2141099568
- Cited by
- 212
- References
- 0
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli. https://app.cochat.ai/papers/10.1128/jb.177.14.4194-4197.1995
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- Brown, E. D., Vivas, E. I., Walsh, C. T., & Kolter, R. (1995). MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli. Journal of Bacteriology. https://doi.org/10.1128/jb.177.14.4194-4197.1995
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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