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Escherichia coli peptide methionine sulfoxide reductase gene: regulation of expression and role in protecting against oxidative damage
Open accessAbstract
The Escherichia coli peptide methionine sulfoxide reductase gene (msrA) encodes a single-subunit polypeptide of 212 amino acid residues (M. A. Rahman, H. Nelson, H. Weissbach, and N. Brot, J. Biol. Chem. 267:15549-15551, 1992). RNA blot analysis showed that the gene is transcribed into an mRNA of about 850 nucleotides. The promoter region was characterized, and the transcription initiation site was identified by primer extension. The synthesis of the MsrA protein increased about threefold in a growth-phase-dependent fashion. In an attempt to define the in vivo role of msrA, a chromosomal disruption was constructed. This mutant was more sensitive to oxidative stress, suggesting that oxidation of methionine in proteins plays an important role in oxidative damage.
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“Significantly, methionine sulfoxide reductase knockout bacteria are sensitized to the cell killing effects of hydrogen peroxide [33,34].”
From Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase (2021) · cites this paper as [33]
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Metadata
- Authors
- Moskovitz, J., Rahman, M. A., Strassman, J., Yancey, S. O., Kushner, S. R., Brot, N., & Weissbach, H.
- Affiliations
- Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1995-02
- Volume
- 177
- Issue
- 3
- Pages
- 502-507
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC176620
- OpenAlex
- W2107508146
- Cited by
- 294
- References
- 31
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 4 · 2016: 9 · 2015: 9 · 2014: 3 · 2013: 10 · 2012: 7
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Bacteriology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KU ScholarWorks (University of Kansas) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Keywords
- Escherichia coli, msrA gene, methionine sulfoxide reductase, gene expression regulation, promoter analysis, transcription start sites, oxidative stress sensitivity, oxidative damage protection
- MeSH terms
- Base Sequence, Escherichia coli, Genes, Bacterial, Methionine, Molecular Sequence Data, Mutation, Oxidoreductases, RNA, Messenger, Gene Expression Regulation, Bacterial, Oxidative Stress, Methionine Sulfoxide Reductases
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