The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment
Open accessAbstract
The Saccharomyces cerevisiae gene MEC1 represents a structural homolog of the human gene ATM mutated in ataxia telangiectasia patients. Like human ataxia telangiectasia cell lines, mec1 mutants are defective in G2 and S-phase cell cycle checkpoints in response to radiation treatment. Here we show an additional defect in G1 arrest following treatment with UV light or gamma rays and map a defective arrest stage at or upstream of START in the yeast cell cycle.
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In Saccharomyces cerevisiae, Mec1 protein kinase is the most important component of the damage checkpoint and is the yeast homologue of human ATR.
“In Saccharomyces cerevisiae, the most important of these is the Mec1 protein kinase, the yeast homologue of human ATR (26, 39, 45).”
From A Role for Checkpoint Kinase-Dependent Rad26 Phosphorylation in Transcription-Coupled DNA Repair in <i>Saccharomyces cerevisiae</i> (2010) · cites this paper as [45]
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References 24 · Cited by 50
- Authors
- Siede, W., Allen, J. B., Elledge, S. J., & Friedberg, E. C.
- Affiliations
- Emory University (US)
- ORCID
- Elledge, S J
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1996-10
- Volume
- 178
- Issue
- 19
- Pages
- 5841-5843
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC178434
- OpenAlex
- W2110085980
- Cited by
- 50
- References
- 24
- Citations by year
- 2022: 1 · 2021: 2 · 2019: 1 · 2017: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Bacteriology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA 12428)
- National Institute of General Medical Sciences (GM44644)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- Saccharomyces cerevisiae, G1 cell cycle arrest, radiation response, ultraviolet radiation, gamma radiation, cell cycle checkpoints, START checkpoint, ataxia telangiectasia, DNA damage response
- MeSH terms
- Mating Factor, Ataxia Telangiectasia, Cell Cycle, DNA-Binding Proteins, Dose-Response Relationship, Radiation, Fungal Proteins, Genes, Fungal, Humans, Peptides, Proteins, Saccharomyces cerevisiae, Ultraviolet Rays, Nocodazole, Protein Serine-Threonine Kinases, Sequence Homology, Cell Cycle Proteins, Tumor Suppressor Proteins, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins, Ataxia Telangiectasia Mutated Proteins
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