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Two-component regulatory systems can interact to process multiple environmental signals
Open accessAbstract
The PhoP/PhoQ two-component system of Salmonella typhimurium governs transcription of some 25 loci in response to the extracellular concentration of Mg2+. We have now identified one of these loci as pmrCAB, which codes for a two-component system that mediates resistance to the antibiotic polymyxin B. Transcription of seven of 25 PhoP-activated loci was dependent on a functional PmrA protein, the response regulator of the PmrA/PmrB system. Expression of the PmrA-dependent loci was induced by either Mg2+ limitation or mild acidification, whereas transcription of a PmrA-independent gene was activated by Mg2+ limitation but not acid pH. Induction of PmrA-activated genes by Mg2 limitation required the PhoP and PhoQ proteins. In contrast, the acid-mediated activation of PmrA-regulated genes occurred in strains that were missing either one of these proteins. Transcriptional regulation by a cascade of two-component systems allows pathogenic bacteria to express their virulence determinants in response to a broader spectrum of environmental cues.
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Citations
Cited by
The Pleiotropic Two-Component Regulatory System PhoP-PhoQ
Groisman, E. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.6.1835-1842.2001 · Cited by 887
Self-citationGunn, J. S., Lim, K. B., Krueger, J., Kim, K., Guo, L., Hackett, M., & Miller, S. I. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00757.x · Cited by 655
Cirillo, D. M., Valdivia, R. H., Monack, D. M., & Falkow, S. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01048.x · Cited by 628
Sperandio, V., Torres, A. G., & Kaper, J. B. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02803.x · Cited by 517
Resurgence of Colistin: A Review of Resistance, Toxicity, Pharmacodynamics, and Dosing
Lim, L. M., Ly, N., Anderson, D., Yang, J. C., Macander, L., Jarkowski, A., Forrest, A., Bulitta, J. B., & Tsuji, B. T. (2010) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.30.12.1279 · Cited by 444
Metadata
- Authors
- Soncini, F. C., & Groisman, E. A.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1996-12
- Volume
- 178
- Issue
- 23
- Pages
- 6796-6801
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2151387894
- Cited by
- 209
- References
- 0
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Soncini, F. C., & Groisman, E. A. (1996). Two-component regulatory systems can interact to process multiple environmental signals. Journal of Bacteriology. https://doi.org/10.1128/jb.178.23.6796-6801.1996
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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