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Radioresistance of Deinococcus radiodurans: functions necessary to survive ionizing radiation are also necessary to survive prolonged desiccation
Open accessAbstract
Forty-one ionizing radiation-sensitive strains of Deinococcus radiodurans were evaluated for their ability to survive 6 weeks of desiccation. All exhibited a substantial loss of viability upon rehydration compared with wild-type D. radiodurans. Examination of chromosomal DNA from desiccated cultures revealed a time-dependent increase in DNA damage, as measured by an increase in DNA double-strand breaks. The evidence presented suggests that D. radiodurans' ionizing radiation resistance is incidental, a consequence of this organism's adaptation to a common physiological stress, dehydration.
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“Other common adaptations improve DNA repair mechanisms; these are particularly important for organisms exposed to high doses of radiation or subjected to severe desiccation (e.g., Potts, 1994; Mattimore and Battista, 1996).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Mattimore and Battista, 1996
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Metadata
- Authors
- Mattimore, V, & Battista, J. R.
- Affiliations
- Louisiana State University (US)
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1996-02
- Volume
- 178
- Issue
- 3
- Pages
- 633-637
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC177705
- OpenAlex
- W2145301542
- Cited by
- 687
- References
- 19
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 23 · 2023: 27 · 2022: 19 · 2021: 22 · 2020: 27 · 2019: 27 · 2018: 33 · 2017: 33 · 2016: 28 · 2015: 35 · 2014: 33 · 2013: 28 · 2012: 26
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Bacteriology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Institut de Radioprotection et de SÛreté Nucléaire
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Tardigrade Biology and Ecology
- Keywords
- Deinococcus radiodurans, radioresistance (biology), ionizing radiation, desiccation tolerance, dehydration stress, DNA double-strand breaks, DNA damage, radiation-sensitive mutants, stress adaptation
- MeSH terms
- Desiccation, DNA Damage, DNA Repair, Micrococcus, Radiation Tolerance
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