Complementary and Overlapping Selectivity of the Two-Peptide Bacteriocins Plantaricin EF and JK
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Plantaricin EF and JK are both two-peptide bacteriocins produced by Lactobacillus plantarum C11. The mechanism of plantaricin EF and JK action was studied on L. plantarum 965 cells. Both plantaricins form pores in the membranes of target cells and dissipate the transmembrane electrical potential (Deltapsi) and pH gradient (DeltapH). The plantaricin EF pores efficiently conduct small monovalent cations, but conductivity for anions is low or absent. Plantaricin JK pores show high conductivity for specific anions but low conductivity for cations. These data indicate that L. plantarum C11 produces bacteriocins with complementary ion selectivity, thereby ensuring efficient killing of target bacteria.
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PlnEF and PlnJK are class IIb two-peptide bacteriocins that require about equimolar amounts of the monomers in order to obtain maximal antimicrobial activity.
“PlnEF and PlnJK are class IIb two-peptide bacteriocins that require about equimolar amounts of the monomers in order to obtain maximal antimicrobial activity [55].”
From Genomic Characterization of Lactiplantibacillus plantarum Strains: Potential Probiotics from Ethiopian Traditional Fermented Cottage Cheese (2024) · cites this paper as [55]
The introduction identifies PlnEF and PlnJK as two-peptide class II bacteriocins and reports that equimolar PlnE and PlnF greatly enhance each other’s antimicrobial activity. It says PlnJ and PlnK are effective together, and Materials and Methods says both pairs were tested at a 1:1 ratio. The paper does not establish that an approximately equimolar ratio is required for maximal antimicrobial activity, particularly for PlnJK. (LLM, conf=0.86)
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References 24 · Cited by 116
- Authors
- Moll, G. N., van den Akker, E., Hauge, H. H., Nissen-Meyer, J., Nes, I. F., Konings, W. N., & Driessen, A. J. M.
- Affiliations
- University of Groningen (NL)
- Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9751NN Haren, The Netherlands,1 and
- University of Oslo (NO)
- Department of Chemistry and Biotechnology, Agricultural University of Norway, N-1432 Ås,3 Norway
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1999-08-15
- Volume
- 181
- Issue
- 16
- Pages
- 4848-4852
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC93971
- OpenAlex
- W2113373485
- Cited by
- 116
- References
- 24
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 5 · 2012: 6
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Bacteriology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- two-peptide bacteriocin, Lactobacillus plantarum, pore formation, ion selectivity, membrane potential, pH gradient
- MeSH terms
- Anions, Bacteriocins, Biological Transport, Cations, Monovalent, Fluoresceins, Fluorescent Dyes, Hydrogen-Ion Concentration, Lactobacillus, Membrane Potentials, Rubidium Radioisotopes, Glutamic Acid
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