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Influence of Mutations in the mexR Repressor Gene on Expression of the MexA-MexB-OprM Multidrug Efflux System of Pseudomonas aeruginosa
Open accessAbstract
Several nalB -type multidrug-resistant mutants of Pseudomonas aeruginosa overexpressed MexAB-OprM and carried mutations in the local regulatory gene, mexR . Others, dubbed nalC types, carried mutations elsewhere and overexpressed MexAB-OprM less extensively than the nalB strains. Available evidence showed that MexR acted solely as repressor. Disruption of the mexR gene at various places suggested that the 5′ end of mexR may be a part of the mexAB-oprM promoter.
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Citations
Cited by
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Grkovic, S., Brown, M. H., & Skurray, R. A. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.4.671-701.2002 · Cited by 423
Quale, J., Bratu, S., Gupta, J., & Landman, D. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.5.1633-1641.2006 · Cited by 409
Efflux-Mediated Resistance to Tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1
Dean, C. R., Visalli, M. A., Projan, S. J., Sum, P.-E., & Bradford, P. A. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.3.972-978.2003 · Cited by 286
Metadata
- Authors
- Srikumar, R., Paul, C. J., & Poole, K.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2000-03
- Volume
- 182
- Issue
- 5
- Pages
- 1410-1414
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2117506315
- Cited by
- 160
- References
- 0
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Influence of Mutations in the mexR Repressor Gene on Expression of the MexA-MexB-OprM Multidrug Efflux System of Pseudomonas aeruginosa. https://app.cochat.ai/papers/10.1128/jb.182.5.1410-1414.2000
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- Srikumar, R., Paul, C. J., & Poole, K. (2000). Influence of Mutations in the mexR Repressor Gene on Expression of the MexA-MexB-OprM Multidrug Efflux System of Pseudomonas aeruginosa. Journal of Bacteriology. https://doi.org/10.1128/jb.182.5.1410-1414.2000
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
