The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Alpha-Toxin Is Required for Biofilm Formation by Staphylococcus aureus
Open accessAbstract
Staphylococcus aureus is a common pathogen associated with nosocomial infections. It can persist in clinical settings and gain increased resistance to antimicrobial agents through biofilm formation. We have found that alpha-toxin, a secreted, multimeric, hemolytic toxin encoded by the hla gene, plays an integral role in biofilm formation. The hla mutant was unable to fully colonize plastic surfaces under both static and flow conditions. Based on microscopy studies, we propose that alpha-hemolysin is required for cell-to-cell interactions during biofilm formation.
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Heilmann, C., Hussain, M., Peters, G., & Götz, F. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.4101774.x · Cited by 700
Marrie, T. J., & Costerton, J. W. (1984) · Journal of Clinical Microbiology · doi:10.1128/jcm.19.5.687-693.1984 · Cited by 327 · cited 1×
“Staphylococcus aureus is capable of biofilm formation, which increases its persistence and boosts its levels of antimicrobial resistance (5), and biofilms of this organism have been observed on surfaces ranging from intravascular catheters to pacemaker leads (17, 18).”
Background
Cited by
agr-Mediated Dispersal of Staphylococcus aureus Biofilms
Boles, B. R., & Horswill, A. R. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000052 · Cited by 963
LaPlante, K. L., & Rybak, M. J. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.12.4665-4672.2004 · Cited by 284
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Sureda, A., Daglia, M., Argüelles Castilla, S., Sanadgol, N., Fazel Nabavi, S., Khan, H., Belwal, T., Jeandet, P., Marchese, A., Pistollato, F., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104582 · Cited by 143
Venkateswara Prasad, U., Vasu, D., Yeswanth, S., Swarupa, V., Sunitha, M. M., Choudhary, A., & Sarma, P. V. G. K. (2015) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.959945 · Cited by 18
Metadata
- Authors
- Caiazza, N. C., & O'Toole, G. A.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2003-05-15
- Volume
- 185
- Issue
- 10
- Pages
- 3214-3217
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2124346064
- Cited by
- 216
- References
- 2
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Caiazza, N. C., & O'Toole, G. A. (2003). Alpha-Toxin Is Required for Biofilm Formation by Staphylococcus aureus. Journal of Bacteriology. https://doi.org/10.1128/jb.185.10.3214-3217.2003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
