The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Two Genetic Loci Produce Distinct Carbohydrate-Rich Structural Components of the Pseudomonas aeruginosa Biofilm Matrix
Open accessAbstract
Pseudomonas aeruginosa forms biofilms, which are cellular aggregates encased in an extracellular matrix. Molecular genetics studies of three common autoaggregative phenotypes, namely wrinkled colonies, pellicles, and solid-surface-associated biofilms, led to the identification of two loci,pel and psl, that are involved in the production of carbohydrate-rich components of the biofilm matrix. The pel gene cluster is involved in the production of a glucose-rich matrix material in P. aeruginosa strain PA14 (L. Friedman and R. Kolter, Mol. Microbiol.51:675-690, 2004). Here we investigate the role of the pel gene cluster in P. aeruginosa strain ZK2870 and identify a second genetic locus, termed psl, involved in the production of a mannose-rich matrix material. The 11 predicted protein products of the psl genes are homologous to proteins involved in carbohydrate processing.P. aeruginosa is thus able to produce two distinct carbohydrate-rich matrix materials. Either carbohydrate-rich matrix component appears to be sufficient for mature biofilm formation, and at least one of them is required for mature biofilm formation in P. aeruginosa strains PA14 and ZK2870.
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Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Nakai, K., & Horton, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01336-x · Cited by 2,181 · cited 1×
“transmembrane domains of the predicted proteins (10, 18).”
BackgroundPseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm
Sauer, K., Camper, A. K., Ehrlich, G. D., Costerton, J. W., & Davies, D. G. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.4.1140-1154.2002 · Cited by 1,691
Fruiting body formation by Bacillus subtilis
Branda, S. S., González-Pastor, J. E., Ben-Yehuda, S., Losick, R., & Kolter, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191384198 · Cited by 1,129
Self-citationPseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
Drenkard, E., & Ausubel, F. M. (2002) · Nature · doi:10.1038/416740a · Cited by 997
Cited by
Physiological heterogeneity in biofilms
Stewart, P. S., & Franklin, M. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1838 · Cited by 2,327
Hickman, J. W., Tifrea, D. F., & Harwood, C. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507170102 · Cited by 836
Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix
Ma, L., Conover, M., Lu, H., Parsek, M. R., Bayles, K., & Wozniak, D. J. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000354 · Cited by 699
Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis
Tamayo, R., Pratt, J. T., & Camilli, A. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093426 · Cited by 486
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Metadata
- Authors
- Friedman, L., & Kolter, R.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2004-07-15
- Volume
- 186
- Issue
- 14
- Pages
- 4457-4465
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2126879410
- Cited by
- 537
- References
- 5
- Type
- conference abstract
- Language
- en
- Open access
- green
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