Global Transcriptome Analysis of Staphylococcus aureus Response to Hydrogen Peroxide
Open accessAbstract
Staphylococcus aureus responds with protective strategies against phagocyte-derived reactive oxidants to infect humans. Herein, we report the transcriptome analysis of the cellular response of S. aureus to hydrogen peroxide-induced oxidative stress. The data indicate that the oxidative response includes the induction of genes involved in virulence, DNA repair, and notably, anaerobic metabolism.
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These data fit with previous work which shows that the expression of umuC, but not dinB, is increased in response to H2O2.
“These data fit with previous work which shows that the expression of umuC, but not dinB, is increased in response to H2O2 (56).”
From Staphylococcus aureus Adapts to Oxidative Stress by Producing H <sub>2</sub> O <sub>2</sub> -Resistant Small-Colony Variants via the SOS Response (2015) · cites this paper as [56]
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References 64 · Cited by 152
- Authors
- Chang, W., Small, D. A., Toghrol, F., & Bentley, W. E.
- Affiliations
- University of Maryland Biotechnology Institute (US)
- Environmental Protection Agency (US)
- Corresponding author
- Toghrol, Freshteh
- ORCID
- Bentley, William E.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2006-02-15
- Volume
- 188
- Issue
- 4
- Pages
- 1648-1659
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC1367260
- OpenAlex
- W2141355399
- Cited by
- 152
- References
- 64
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 14 · 2020: 5 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 11 · 2015: 13 · 2014: 6 · 2013: 8 · 2012: 11
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Bacteriology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- Staphylococcus aureus, hydrogen peroxide, oxidative stress response, transcriptome, virulence genes, DNA repair, anaerobic metabolism, bacterial gene expression
- MeSH terms
- Genes, Bacterial, Hydrogen Peroxide, RNA, Bacterial, RNA, Messenger, Staphylococcus aureus, Time Factors, Transcription, Genetic, Gene Expression Regulation, Bacterial, Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling
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