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Macromolecule Synthesis in Temperature-sensitive Mutants of Yeast
Open accessAbstract
Approximately 400 temperature-sensitive mutants of Saccharomyces cerevisiae were isolated. The mutants were unable to form colonies on enriched media at 36 C, but grew normally, or nearly so, at 23 C. The mutants were tested for loss of viability, change in morphology, increase in cell number, and the ability to synthesize protein, ribonucleic acid (RNA), and deoxyribonucleic acid (DNA) after a shift from 23 to 36 C. Mutations were found which resulted in a preferential loss of ability to carry out protein synthesis, RNA synthesis, DNA synthesis, cell division, or cell-wall formation. Diploid cells heterozygous for the temperature-sensitive mutations were constructed and tested for their ability to form colonies at 36 C. Four mutations dominant to their wild-type allele were identified.
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Citations
Cited by
TOR, a Central Controller of Cell Growth
Schmelzle, T., & Hall, M. N. (2000) · Cell · doi:10.1016/s0092-8674(00)00117-3 · Cited by 1,924
Coordination of growth with cell division in the yeast
JOHNSTON, G., PRINGLE, J., & HARTWELL, L. (1977) · Experimental Cell Research · doi:10.1016/0014-4827(77)90154-9 · Cited by 827
Self-citationGenetic Control of the Cell-Division Cycle in Yeast, I. Detection of Mutants
Hartwell, L. H., Culotti, J., & Reid, B. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.66.2.352 · Cited by 561
Self-citationUnequal division in Saccharomyces cerevisiae and its implications for the control of cell division.
Hartwell, L. H., & Unger, M. W. (1977) · The Journal of cell biology · doi:10.1083/jcb.75.2.422 · Cited by 555
Self-citationBender, A., & Pringle, J. R. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.3.1295-1305.1991 · Cited by 170
Metadata
- Authors
- Hartwell, L. H.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1967-05
- Volume
- 93
- Issue
- 5
- Pages
- 1662-1670
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1811297709
- Cited by
- 701
- References
- 0
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Hartwell, L. H. (1967). Macromolecule Synthesis in Temperature-sensitive Mutants of Yeast. Journal of Bacteriology. https://doi.org/10.1128/jb.93.5.1662-1670.1967
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