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Lytic Effects of Staphylococcal α-Toxin and δ-Hemolysin
Abstract
Several preparations of staphylococcal α-toxin and δ-lysin were studied in order to compare hemolytic activity with capacity to lyse bacterial protoplasts. δ-Lysin in relatively low concentration lysed protoplasts of Sarcina lutea , protoplasts of Streptococcus faecalis , and spheroplasts of Escherichia coli . Lysis of bacterial protoplasts by preparations of α-toxin appeared to be due to contamination of the preparations with δ-lysin. Data comparing the protoplast-lysing activity of various lytic agents are presented.
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“Our model proposes that during a blood-borne infection, S. aureus encounters red blood cells that are lysed via the secretion of potent hemolysins (3).”
From Staphylococcus aureus IsdB Is a Hemoglobin Receptor Required for Heme Iron Utilization (2006) · cites this paper as [3]
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Research works printed but not linked: 10
- Arbuthnott , J. P. , J. H. Freer , and A. W. Bernheimer . 1967 . Physical states of staphylococcal oa-toxin . J. Bacteriol. 94 : 1170 - 1177 . · DOI
- Bernheimer , A. W. 1966 . Disruption of wall-less bacteria by streptococcal and staphylococcal toxins . J. Bacteriol. 91 : 1677 - 1680 . · DOI
- Bernheimer , A. W. , and L. L. Schwartz . 1963 . Isolation and composition of staphylococcal a-toxin . J. Gen. Microbiol. 30 : 455 - 468 . · DOI · Paper page
- Bernheimer , A. W. , and L. L. Schwartz . 1965 . Lysis of bacterial protoplasts and spheroplasts by staphylococcal a-toxin and streptolysin S . J. Bacteriol. 89 : 1387 - 1392 . · doi:10.1128/jb.89.5.1387-1392.1965
- Freer , J. H. , J. P. Arbuthnott , and A. W. Bernheimer . 1968 . Interaction of staphylococcal a-toxin with artificial and natural membranes . J. Bacteriol. 95 : 1153 - 1168 . · DOI
- Gladstone , G. P. , and A. Yoshida . 1967 . The cytopathic action of purified staphylococcal 5-haemolysin . Brit. J. Exptl. Pathol. 48 : 11 - 19 .
- Habermann E. 1965. Recent studies on Hymenoptera venoms p. 53-62. In H. W. Raudonat and J. Vanecek (ed.) Recent advances in the pharmacology of toxins. Pergamon Press Oxford. · doi:10.1016/b978-0-08-010811-7.50010-1
- Jackson , A. W. , and R. M. Little . 1958 . Staphylococcal toxins. II. Factors affecting hemolysis by a-lysin . Can. J. Microbiol. 4 : 435 - 444 . · doi:10.1139/m58-046
- Lominski , I. , J. P. Arbuthnott , and J. B. Spence . 1963 . Purification of staphylococcus alpha toxin . J. Pathol. Bacteriol. 86 : 258 - 262 . · doi:10.1002/path.1700860138
- Marks , J. , and A. C. T. Vaughan . 1950 . Staphylococcal 8-hemolysin . J. Pathol. Bacteriol. 62 : 597 - 615 . · doi:10.1002/path.1700620411
Cited by
Passage of Heme-Iron Across the Envelope of Staphylococcus aureus
Mazmanian, S. K., Skaar, E. P., Gaspar, A. H., Humayun, M., Gornicki, P., Jelenska, J., Joachmiak, A., Missiakas, D. M., & Schneewind, O. (2003) · Science · doi:10.1126/science.1081147 · Cited by 593
Iron-Source Preference of Staphylococcus aureus Infections
Skaar, E. P., Humayun, M., Bae, T., DeBord, K. L., & Schneewind, O. (2004) · Science · doi:10.1126/science.1099930 · Cited by 440
Staphylococcus aureus IsdB Is a Hemoglobin Receptor Required for Heme Iron Utilization
Torres, V. J., Pishchany, G., Humayun, M., Schneewind, O., & Skaar, E. P. (2006) · Journal of Bacteriology · doi:10.1128/jb.01335-06 · Cited by 302
A Staphylococcus aureus Regulatory System that Responds to Host Heme and Modulates Virulence
Torres, V. J., Stauff, D. L., Pishchany, G., Bezbradica, J. S., Gordy, L. E., Iturregui, J., Anderson, K. L., Dunman, P. M., Joyce, S., & Skaar, E. P. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.03.001 · Cited by 241
Staphylococcus aureus Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes
Spaan, A. N., Reyes-Robles, T., Badiou, C., Cochet, S., Boguslawski, K. M., Yoong, P., Day, C. J., de Haas, C. J. C., van Kessel, K. P. M., Vandenesch, F., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.08.001 · Cited by 114
Metadata
- Authors
- Bernheimer, A. W., Avigad, L. S., & Grushoff, P.
- Affiliations
- Department of Microbiology, New York University School of Medicine, New York, New York 10016
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1968-08
- Volume
- 96
- Issue
- 2
- Pages
- 487-491
- ISSN
- 0021-9193
- 1098-5530
- Cited by
- 30
- References
- 0
- Language
- en
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
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- Bernheimer, A. W., Avigad, L. S., & Grushoff, P. (1968). Lytic Effects of Staphylococcal α-Toxin and δ-Hemolysin. Journal of Bacteriology. https://doi.org/10.1128/jb.96.2.487-491.1968
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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