Cited by 323Chronic Obstructive Pulmonary Disease (COPD) ResearchOral microbiology and periodontitis researchAsthma and respiratory diseases

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Airway Microbiome Dynamics in Exacerbations of Chronic Obstructive Pulmonary Disease

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Huang, Yvonne J., Sethi, Sanjay, Murphy, Timothy, Nariya, Snehal, Boushey, Homer A., Lynch, Susan V.·2014·Journal of Clinical Microbiology

DOI 10.1128/jcm.00035-14PMC PMC4136157

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Abstract

Specific bacterial species are implicated in the pathogenesis of exacerbations of chronic obstructive pulmonary disease (COPD). However, recent studies of clinically stable COPD patients have demonstrated a greater diversity of airway microbiota, whose role in acute exacerbations is unclear. In this study, temporal changes in the airway microbiome before, at the onset of, and after an acute exacerbation were examined in 60 sputum samples collected from subjects enrolled in a longitudinal study of bacterial infection in COPD. Microbiome composition and predicted functions were examined using 16S rRNA-based culture-independent profiling methods. Shifts in the abundance (≥ 2-fold, P < 0.05) of many taxa at exacerbation and after treatment were observed. Microbiota members that were increased at exacerbation were primarily of the Proteobacteria phylum, including nontypical COPD pathogens. Changes in the bacterial composition after treatment for an exacerbation differed significantly among the therapy regimens clinically prescribed (antibiotics only, oral corticosteroids only, or both). Treatment with antibiotics alone primarily decreased the abundance of Proteobacteria, with the prolonged suppression of some microbiota members being observed. In contrast, treatment with corticosteroids alone led to enrichment for Proteobacteria and members of other phyla. Predicted metagenomes of particular microbiota members involved in these compositional shifts indicated exacerbation-associated loss of functions involved in the synthesis of antimicrobial and anti-inflammatory products, alongside enrichment in functions related to pathogen-elicited inflammation. These trends reversed upon clinical recovery. Further larger studies will be necessary to determine whether specific compositional or functional changes detected in the airway microbiome could be useful indicators of exacerbation development or outcome.

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Authors: Huang, Y. J., Sethi, S., Murphy, T., Nariya, S., Boushey, H. A., & Lynch, S. V.
Affiliations: University of California, San Francisco (US)
Buffalo VA Medical Center (US)
University at Buffalo, State University of New York (US)
ORCID: Huang, Yvonne J.
Sethi, Sanjay
Murphy, Timothy
Boushey, Homer A.
Lynch, Susan V.
Venue: Journal of Clinical Microbiology
Publisher: American Society for Microbiology
Published: 2014-08
Volume: 52
Issue: 8
Pages: 2813-2823
ISSN: 0095-1137 (ISSN-L)
1098-660X
DOI: 10.1128/jcm.00035-14
PMC: PMC4136157
OpenAlex: W2135623379
Cited by: 323
References: 48
Citations by year: 2026: 11 · 2025: 12 · 2024: 25 · 2023: 25 · 2022: 30 · 2021: 33 · 2020: 35 · 2019: 28 · 2018: 24 · 2017: 38 · 2016: 27 · 2015: 29 · 2014: 6
FWCI: 26.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Clinical Microbiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (K23HL105572, HL105572)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords: chronic obstructive pulmonary disease, COPD exacerbations, airway microbiome, sputum microbiota, Proteobacteria, antibiotic therapy, oral corticosteroids, inflammation
MeSH terms: Aged, Aged, 80 and over, DNA, Bacterial, DNA, Ribosomal, Humans, Longitudinal Studies, Male, Middle Aged, Phylogeny, Respiratory System, RNA, Ribosomal, 16S, Sputum, Cluster Analysis, Sequence Analysis, DNA, Proteobacteria, Pulmonary Disease, Chronic Obstructive, Microbiota

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Airway Microbiome Dynamics in Exacerbations of Chronic Obstructive Pulmonary Disease

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