The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR Method
Open accessAbstract
Four human coronaviruses (HCoV-229E, HCoV-HKU1, HCoV-NL63, and HCoV-OC43) are associated with a range of respiratory outcomes, including bronchiolitis and pneumonia. Their epidemiologies and clinical characteristics are poorly described and are often reliant on case reports. To address these problems, we conducted a large-scale comprehensive screening for all four coronaviruses by analysis of 11,661 diagnostic respiratory samples collected in Edinburgh, United Kingdom, over 3 years between July 2006 and June 2009 using a novel four-way multiplex real-time reverse transcription-PCR (RT-PCR) assay. Coronaviruses were detected in 0.3 to 0.85% of samples in all age groups. Generally, coronaviruses displayed marked winter seasonality between the months of December and April and were not detected in summer months, which is comparable to the pattern seen with influenza viruses. HCoV-229E was the exception; detection was confined to the winter of 2008 and was sporadic in the following year. There were additional longer-term differences in detection frequencies between seasons, with HCoV-OC43 predominant in the first and third seasons and HCoV-HKU1 dominating in the second (see Results for definitions of seasons). A total of 11 to 41% of coronaviruses detected were in samples testing positive for other respiratory viruses, although clinical presentations of coronavirus monoinfections were comparable to those of viruses which have an established role in respiratory disease, such as respiratory syncytial virus, influenza virus, and parainfluenza viruses. The novel multiplex assay for real-time pan-coronavirus detection enhances respiratory virus diagnosis, overcomes potential diagnostic problems arising through seasonal variation in coronavirus frequency, and provides novel insights into the epidemiology and clinical implications of coronaviruses.
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1 retracted
Woo, P. C. Y., Lau, S. K. P., Wong, B. H. L., Chan, K., Hui, W.-T., Kwan, G., Peiris, M. J. S., Couch, R. B., & Yuen, K. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.12.5885-5888.2004 · Cited by 86
RetractedWoo, P. C. Y., Lau, S. K. P., Chu, C.-M., Chan, K.-H., Tsoi, H.-W., Huang, Y., Wong, B. H. L., Poon, R. W. S., Cai, J. J., Luk, W.-K., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.2.884-895.2005 · Cited by 1,525
Rapid and quantitative detection of human adenovirus DNA by real‐time PCR
Heim, A., Ebnet, C., Harste, G., & Pring‐Åkerblom, P. (2003) · Journal of Medical Virology · doi:10.1002/jmv.10382 · Cited by 820
EPIDEMIOLOGY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION IN WASHINGTON, D.C.
KIM, H. W., ARROBIO, J. O., BRANDT, C. D., JEFFRIES, B. C., PYLES, G., REID, J. L., CHANOCK, R. M., & PARROTT, R. H. (1973) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a121550 · Cited by 556
Templeton, K. E., Scheltinga, S. A., Beersma, M. F. C., Kroes, A. C. M., & Claas, E. C. J. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.4.1564-1569.2004 · Cited by 468
Self-citationEPIDEMIOLOGY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION IN WASHINGTON, D.C.
PARROTT, R. H., KIM, H. W., ARROBIO, J. O., HODES, D. S., MURPHY, B. R., BRANDT, C. D., CAMARGO, E., & CHANOCK, R. M. (1973) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a121558 · Cited by 449
Coronavirus HKU1 and Other Coronavirus Infections in Hong Kong
Lau, S. K. P., Woo, P. C. Y., Yip, C. C. Y., Tse, H., Tsoi, H.-W., Cheng, V. C. C., Lee, P., Tang, B. S. F., Cheung, C. H. Y., Lee, R. A., et al. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.02614-05 · Cited by 442
Evidence of human coronavirus HKU1 and human bocavirus in Australian children
SLOOTS, T., MCERLEAN, P., SPEICHER, D., ARDEN, K., NISSEN, M., & MACKAY, I. (2006) · Journal of Clinical Virology · doi:10.1016/j.jcv.2005.09.008 · Cited by 360
Chiu, S. S., Hung Chan, K., Wing Chu, K., Kwan, S. W., Guan, Y., Man Poon, L. L., & Peiris, J. S. M. (2005) · Clinical Infectious Diseases · doi:10.1086/430301 · Cited by 325
Croup Is Associated with the Novel Coronavirus NL63
van der Hoek, L., Sure, K., Ihorst, G., Stang, A., Pyrc, K., Jebbink, M. F., Petersen, G., Forster, J., Berkhout, B., & Überla, K. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020240 · Cited by 308
Cited by
Wu, J. T., Leung, K., & Leung, G. M. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30260-9 · Cited by 4,389
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
Braun, J., Loyal, L., Frentsch, M., Wendisch, D., Georg, P., Kurth, F., Hippenstiel, S., Dingeldey, M., Kruse, B., Fauchere, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2598-9 · Cited by 1,310
Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dubé, M., & Talbot, P. J. (2019) · Viruses · doi:10.3390/v12010014 · Cited by 1,048
Laboratory diagnosis of emerging human coronavirus infections – the state of the art
Loeffelholz, M. J., & Tang, Y.-W. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1745095 · Cited by 788
Seasonal coronavirus protective immunity is short-lasting
Edridge, A. W. D., Kaczorowska, J., Hoste, A. C. R., Bakker, M., Klein, M., Loens, K., Jebbink, M. F., Matser, A., Kinsella, C. M., Rueda, P., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1083-1 · Cited by 767
Metadata
- Authors
- Gaunt, E. R., Hardie, A., Claas, E. C. J., Simmonds, P., & Templeton, K. E.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2010-08
- Volume
- 48
- Issue
- 8
- Pages
- 2940-2947
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W2041352768
- Cited by
- 699
- References
- 35
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Gaunt, E. R., Hardie, A., Claas, E. C. J., Simmonds, P., & Templeton, K. E. (2010). Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR Method. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.00636-10
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