Impact of rpoB Mutations on Reduced Vancomycin Susceptibility in Staphylococcus aureus
Open accessAbstract
Of 38 vancomycin-intermediate Staphylococcus aureus (VISA) clinical strains, 27 (71%) possessed a mutation(s) in rpoB encoding the β-subunit of RNA polymerase. Furthermore, 95.6% of the rifampin-resistant mutants obtained from 9 methicillin-resistant S. aureus (MRSA) clinical isolates showed decreased vancomycin susceptibilities. These data indicate the involvement of an rpoB mutation in VISA phenotype expression.
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Another change frequently associated with the VISA phenotype is mutations in rpoB (encoding the B subunit of the RNA polymerase).
“Apart from the above regulatory systems, another change that has been frequently associated with the VISA phenotype is mutations in rpoB (encoding the B subunit of the RNA polymerase).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [105]
Watanabe et al. analyzed 38 VISA isolates from 10 different countries and demonstrated that mutations in the rpoB gene were present in the majority (71%) of the isolates.
“Indeed, Watanabe et al. analyzed 38 VISA isolates from 10 different countries and demonstrated that mutations in the rpoB gene were present in the majority (71%) of the isolates (105).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [105]
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References 22 · Cited by 127
- Authors
- Watanabe, Y., Cui, L., Katayama, Y., Kozue, K., & Hiramatsu, K.
- Affiliations
- Department of Infection Control Science, Graduate School of Medicine
- Juntendo University (JP)
- Corresponding author
- Hiramatsu, Keiichi
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2011-07
- Volume
- 49
- Issue
- 7
- Pages
- 2680-2684
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC3147882
- OpenAlex
- W2167909654
- Cited by
- 127
- References
- 22
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 8 · 2021: 12 · 2020: 6 · 2019: 8 · 2018: 13 · 2017: 5 · 2016: 12 · 2015: 9 · 2014: 7 · 2013: 12 · 2012: 11
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- rpoB mutations, vancomycin-intermediate Staphylococcus aureus, vancomycin resistance, RNA polymerase beta subunit, methicillin-resistant Staphylococcus aureus, rifampicin resistance, reduced vancomycin susceptibility, antibiotic resistance genes
- MeSH terms
- Humans, Microbial Sensitivity Tests, DNA-Directed RNA Polymerases, Staphylococcal Infections, Staphylococcus aureus, Vancomycin, Mutation, Missense, Vancomycin Resistance
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