Molecular evidence of persistent epidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, foot, and mouth disease in China
Open accessAbstract
The molecular epidemiology of CVA16 in China between 1999 and 2008 reflects a pattern of endemic cocirculation of clusters B1a and B1b within subgenotype B1 viruses. The annual evolution rate of CVA16 was estimated as approximately 0.91 x 10(-2) substitutions per synonymous nucleotide/year and is slightly lower than that of HEV71.
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EV71 and CVA16 are the two major causative agents of HFMD in different areas of mainland China, and other species A coxsackieviruses have also been demonstrated to be involved.
“EV71 and CVA16 are the two major causative agents in different areas, and other coxsackieviruses of species A, such as CVA10, CVA6, CVA4, CVA12, etc, have also been demonstrated to be involved [24]–[26].”
From Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong Province, China, 2006–2012 (2014) · cites this paper as [26]
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References 17 · Cited by 143
- Authors
- Zhang, Y., Wang, D., Yan, D., Zhu, S., Liu, J., Wang, H., Zhao, S., Yu, D., Nan, L., An, J., Chen, L., An, H., Xu, A., & Xu, W.
- Affiliations
- Chinese Center For Disease Control and Prevention (CN)
- Gansu Provincial Center for Disease Control and Prevention (CN)
- Shandong Center for Disease Control and Prevention (CN)
- Qinghai Center for Disease Control and Prevention, Xining 810007, People's Republic of China
- Inner Mongolia Comprehensive Disease Prevention and Control Center (CN)
- Corresponding author
- Xu, Aiqiang
- Xu, Wenbo
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2010-02
- Volume
- 48
- Issue
- 2
- Pages
- 619-622
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC2815627
- OpenAlex
- W2042361543
- Cited by
- 143
- References
- 17
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 8 · 2022: 12 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 12 · 2012: 6
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- coxsackievirus A16, hand, foot and mouth disease, molecular epidemiology, viral evolution rate, co-circulation, epidemic persistence, China
- MeSH terms
- China, Hand, Foot and Mouth Disease, Humans, Molecular Sequence Data, Phylogeny, Polymorphism, Genetic, RNA, Viral, Cluster Analysis, Point Mutation, Sequence Homology, Sequence Analysis, DNA, Evolution, Molecular, Endemic Diseases, Enterovirus A, Human
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