Comparison of Etest, Disk Diffusion, and Broth Macrodilution for In Vitro Susceptibility Testing of Rhodococcus equi
Open accessAbstract
MICs of erythromycin, clarithromycin, azithromycin, rifampin, gentamicin, and doxycycline against 101 isolates of Rhodococcus equi were determined by broth macrodilution, disk diffusion, and Etest. Categorical agreement ranged between 85.1 and 100%. Overall, the agreement between Etest and disk diffusion was better than the agreement between broth macrodilution and the agar-based methods.
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The antimicrobial gradient diffusion test offers an alternative approach for evaluating antimicrobial activity by combining principles of dilution and diffusion of the antimicrobial agent.
“The antimicrobial gradient diffusion test offers an alternative approach for evaluating antimicrobial activity by combining the fundamental principles of dilution and diffusion of the antimicrobial agent [66].”
From Methods for screening and evaluation of antimicrobial activity: A review of protocols, advantages, and limitations (2024) · cites this paper as [66]
Previous studies have shown a good correlation between MIC values determined by Etest and those obtained by broth dilution or agar dilution.
“Several previous studies have shown a good correlation between the MIC values determined by Etest and those obtained by broth dilution or agar dilution method [25], [26], [27].”
From Methods for in vitro evaluating antimicrobial activity: A review (2016) · cites this paper as [26]
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STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965 · see citing works
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Methods for in vitro evaluating antimicrobial activity: A review
Balouiri, M., Sadiki, M., & Ibnsouda, S. K. (2016) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2015.11.005 · Cited by 7,264 · see citing works
Hossain, T. J. (2024) · European Journal of Microbiology and Immunology · doi:10.1556/1886.2024.00035 · Cited by 392 · see citing works
Gerstein, A. C., Rosenberg, A., Hecht, I., & Berman, J. (2016) · Microbiology · doi:10.1099/mic.0.000295 · Cited by 63 · see citing works
- Authors
- Berghaus, L. J., Giguère, S., Guldbech, K., Warner, E., Ugorji, U., & Berghaus, R. D.
- Affiliations
- University of Georgia (US)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2015-01
- Volume
- 53
- Issue
- 1
- Pages
- 314-318
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC4290945
- OpenAlex
- W2081779552
- Cited by
- 59
- References
- 1
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 3
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Food and Drug Administration
- Topics
- Health Sciences › Medicine › Infectious Diseases › Infectious Disease Case Reports and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- Rhodococcus equi, antimicrobial susceptibility testing, E-test, disk diffusion, broth macrodilution, minimum inhibitory concentration, measurement agreement, erythromycin, clarithromycin, azithromycin, rifampicin, gentamicin, doxycycline
- MeSH terms
- Actinomycetales Infections, Animals, Anti-Bacterial Agents, Horse Diseases, Horses, Microbial Sensitivity Tests, Rhodococcus equi, Disk Diffusion Antimicrobial Tests
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