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Cited by 40Microbial infections and disease researchBacterial Infections and VaccinesAnimal health and immunology

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Pulmonary persistence of Haemophilus somnus in the presence of specific antibody

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Gogolewski, R P, Schaefer, D C, Wasson, S K, Corbeil, R R, Corbeil, L B·1989·Journal of Clinical Microbiology
DOI 10.1128/jcm.27.8.1767-1774.1989PMC PMC267669
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Abstract

Chronic experimental Haemophilus somnus pneumonia was produced in five 8- to 12-week-old calves to investigate host-parasite relationships in the respiratory tract. Calves were depressed and pyrexic and coughed intermittently for 3 days and then recovered except for sporadic coughing. Bacteria persisted in the lung for 6 to 10 weeks or more. Immunoglobulin G1 (IgG1), IgG2, and IgM but no IgA antibodies specific for H. somnus were detected in serum. Bronchoalveolar lavage samples contained detectable IgG1, IgG2, IgM, and IgA antibodies specific for H. somnus throughout most of the experiment. The kinetics of the isotypic antibody response against H. somnus in serum and bronchoalveolar lavage fluids differed, suggesting that both local and systemic antibody responses had occurred. Persistence of pulmonary infection for 10 weeks or more in the presence of antibody may be due to an inappropriate distribution of isotypes, toxicity of H. somnus for bovine macrophages, and perhaps other factors. Three of the calves were challenged with a 10-fold-higher dose of H. somnus at 10 weeks after the original inoculation. Immunity against H. somnus was indicated by the rapid clearance of bacteria from the lungs and the presence of minimal pneumonia at necropsy 3 days after bacterial challenge.

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Metadata

Authors
Gogolewski, R. P., Schaefer, D. C., Wasson, S. K., Corbeil, R. R., & Corbeil, L. B.
Affiliations
Washington State University (US)
Venue
Journal of Clinical Microbiology
Publisher
American Society for Microbiology
Published
1989-08
Volume
27
Issue
8
Pages
1767-1774
ISSN
  • 0095-1137 (ISSN-L)
  • 1098-660X
DOI
10.1128/jcm.27.8.1767-1774.1989
PMC
PMC267669
OpenAlex
W1938472486
Cited by
40
References
0
Citations by year
2024: 1 · 2022: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
1.34
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Clinical Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1f32ai007848-01)
  • National Institute of Allergy and Infectious Diseases (1 F32 AI 07848)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal health and immunology
Keywords
Haemophilus somnus, bovine respiratory disease, chronic pneumonia, calves, antibody response, IgA, bronchoalveolar lavage, host-parasite interactions, bovine macrophages, bacterial challenge, immunity
MeSH terms
Animals, Antibodies, Bacterial, Bronchoalveolar Lavage Fluid, Cattle, Cattle Diseases, Cell Count, Haemophilus, Haemophilus Infections, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Lung, Male, Pneumonia, Colony Count, Microbial

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