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A new attempt to distinguish serologically the subspecies of Treponema pallidum causing syphilis and yaws.
Open accessAbstract
In an effort to serologically differentiate syphilis from yaws, 69 monoclonal antibody species raised against Treponema pallidum subsp. pallidum were tested by immunoblotting for their reactivity with Treponema pallidum subsp. pertenue. All monoclonal antibodies reacted with antigens with the same molecular weight of both subspecies. Furthermore, no differences in reactivity between sera from yaws patients and from syphilis patients were found by Western blot (immunoblot) analysis of cell lysates of T. pallidum subsp. pallidum and T. pallidum subsp. pertenue. We tried to exploit the only known molecular difference between the subspecies. The subunits of the 190-kilodalton multimeric proteins TpF1 and TyF1 of T. pallidum subsp. pallidum and T. pallidum subsp. pertenue, respectively, have previously been shown to differ in one amino acid residue at position 40. In this study, no difference was found in immunoreactivity of TpF1 or TyF1 with either syphilis sera or yaws sera. Synthetic peptides based on the sequence of TpF1 and of TyF1 were used in an enzyme-linked immunosorbent assay with syphilis sera and yaws sera. Again, no difference in reactivity between the T. pallidum subsp. pallidum- and T. pallidum subsp. pertenue-derived peptides was observed.
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Existing serologic tests cannot differentiate between syphilis and yaws or other non-venereal treponematoses.
“the fact that existing serologic tests cannot differentiate between syphilis and yaws or other non-venereal treponematoses 28, 29.”
From Audit of antenatal screening for syphilis and HIV in migrant and refugee women on the Thai-Myanmar border: a descriptive study (2015) · cites this paper as [28]
Older age as a risk factor for syphilis is suggestive of another confounder to the analysis, namely that existing serologic tests cannot differentiate between syphilis and yaws or other non-venereal treponematoses.
“This is also suggestive of another confounder to our analysis, the fact that existing serologic tests cannot differentiate between syphilis and yaws or other non-venereal treponematoses 28, 29.”
From Audit of antenatal screening for syphilis and HIV in migrant and refugee women on the Thai-Myanmar border: a descriptive study (2015) · cites this paper as [28]
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References 43 · Cited by 49
Research works printed but not linked: 1
- [18]Hardy, P. H., Jr. 1976. Pathogenic treponemes, p. 107–119. In R. C. Johnson (ed.), The biology of parasitic spirochetes. Academic Press, Inc., New York.
Metadata
- Authors
- Noordhoek, G. T., Cockayne, A., Schouls, L. M., Meloen, R. H., Stolz, E., & van Embden, J. D.
- Affiliations
- National Institute for Public Health and the Environment (NL)
- Laboratory of Bacteriology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
- ORCID
- Schouls, L M
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1990-07
- Volume
- 28
- Issue
- 7
- Pages
- 1600-1607
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC267996
- OpenAlex
- W1537302516
- Cited by
- 49
- References
- 43
- Citations by year
- 2025: 2 · 2022: 2 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- Treponema pallidum subsp. pallidum, Treponema pallidum subsp. pertenue, syphilis, yaws, serological differentiation, monoclonal antibodies, synthetic peptides, serological diagnosis
- MeSH terms
- Amino Acid Sequence, Antibodies, Monoclonal, Antigens, Bacterial, Bacterial Proteins, Humans, Molecular Sequence Data, Serotyping, Species Specificity, Syphilis, Treponema pallidum, Yaws
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