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mecA Gene Is Widely Disseminated in Staphylococcus aureus Population
Open accessAbstract
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important causes of hospital infections worldwide. High-level resistance to methicillin is caused by the mecA gene, which encodes an alternative penicillin-binding protein, PBP 2a. To determine the clonal relationships between methicillin-susceptible S. aureus (MSSA) and MRSA, we typed 1,069 S. aureus isolates (493 MSSA isolates and 576 MRSA isolates), collected mainly in North American and European hospitals between the 1960s and the year 2000, using pulsed-field gel electrophoresis and ribotyping. Of 10 widespread S. aureus lineages recognized, 8 had corresponding mecA -positive strains. Multiresistant MRSA strains are found in hospitals worldwide, while unrelated and more susceptible strains represent less than 1% of the MRSA population. This supports the hypothesis that horizontal transfer plays an important role in the dissemination of the mecA gene in the S. aureus population.
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Citations
Cited by
David, M. Z., & Daum, R. S. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00081-09 · Cited by 1,972
Authority, E. F. S., & European Centre for Disease Prevention and Control (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5182 · Cited by 384
Eady, E. A., & Cove, J. H. (2003) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200304000-00007 · Cited by 329
Metadata
- Authors
- Wielders, C. L. C., Fluit, A. C., Brisse, S., Verhoef, J., & Schmitz, F. J.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2002-11
- Volume
- 40
- Issue
- 11
- Pages
- 3970-3975
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W2130357362
- Cited by
- 231
- References
- 0
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: mecA Gene Is Widely Disseminated in Staphylococcus aureus Population. https://app.cochat.ai/papers/10.1128/jcm.40.11.3970-3975.2002
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- Wielders, C. L. C., Fluit, A. C., Brisse, S., Verhoef, J., & Schmitz, F. J. (2002). mecA Gene Is Widely Disseminated in Staphylococcus aureus Population. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.40.11.3970-3975.2002
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