Human infections caused by thiamine- or menadione-requiring Staphylococcus aureus
Open accessAbstract
Stable dwarf forms of Staphylococcus aureus have been identified in clinical specimens as the sole or predominant isolate in eight cases. These organisms have been shown to be menadione or thiamine dependent, i.e., cultivation in the presence of one of these agents has permitted growth of colonies which appear typical of S. aureus. In vitro resistance to aminoglycosides was overcome by cultivation in the presence of menadione or thiamine. Menadione- or thiamine-requiring S. aureus can be considered as causative agents in severe human infections. Special care must be taken if they are to be identified in pathological specimens. Their antibiotic sensitivity testing should be done comparatively on supplemented and nonsupplemented media.
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References 47 · Cited by 73
Research works printed but not linked: 5
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- Authors
- Acar, J. F., Goldstein, F. W., & Lagrange, P.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1978-08
- Volume
- 8
- Issue
- 2
- Pages
- 142-147
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC275172
- OpenAlex
- W1524126958
- Cited by
- 73
- References
- 47
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Infections and bacterial resistance
- Keywords
- Staphylococcus aureus, aminoglycoside resistance, antimicrobial susceptibility testing, culture medium supplementation, human infection, bacterial identification
- MeSH terms
- Aminoglycosides, Anti-Bacterial Agents, Drug Resistance, Microbial, Humans, Species Specificity, Staphylococcal Infections, Staphylococcus aureus, Thiamine, Vitamin K
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