Animal Models of Zika Virus Infection, Pathogenesis, and Immunity
Open accessAbstract
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has received global attention because of some of its unusual epidemiological and clinical features, including persistent infection in the male reproductive tract and sexual transmission, an ability to cross the placenta during pregnancy and infect the developing fetus to cause congenital malformations, and its association with Guillain-Barré syndrome in adults. This past year has witnessed an intensive effort by the global scientific community to understand the biology of ZIKV and to develop pathogenesis models for the rapid testing of possible countermeasures. Here, we review the recent advances in and utility and limitations of newly developed mouse and nonhuman primate models of ZIKV infection and pathogenesis.
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Observations in ICR suckling mice may provide phenomena for investigating the efficacy of developing drugs or vaccines, and tissues from suckling mice may be used for mechanism discovery.
“There observations in ICR suckling mice may provide the phenomenon for investigation of the efficacy of developing drug or vaccine, and the tissue of the suckling mice may use to underlying the mechanism discovery [20].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [20]
The section on pathogenesis in immunocompetent neonatal mice says these models can help define mechanisms of Zika virus pathogenesis. The section on evaluating vaccines and therapeutics says mouse models, including neonatal models, can be used to assess candidate treatments and vaccines. Neither passage identifies ICR suckling mice or specifically proposes using their tissues for mechanism discovery; page numbers are unavailable in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe ICR suckling mice model is immunocompetent and has allowed researchers to investigate interferon-dependent antiviral compounds or vaccines.
“The ICR suckling mice model are the immunocompetent mice, which have allowed researchers to investigate the interferon-dependent antiviral compounds or vaccine [20, 35].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [20]
The subsection on immunocompetent neonatal mice describes ZIKV studies in wild-type C57BL/6 and Swiss mice, and the vaccine-and-therapeutics subsection says mouse models can be used to evaluate candidate vaccines and therapies (page numbers unavailable in our copy). It mentions ICR mice only in an experiment involving direct inoculation of fetal brains and treatment with convalescent serum—not as a suckling-mouse model used to investigate interferon-dependent antiviral compounds or vaccines. (LLM, conf=0.85)
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References 118 · Cited by 275
- Authors
- Morrison, T. E., & Diamond, M. S.
- Affiliations
- University of Colorado Anschutz (US)
- Washington University in St. Louis (US)
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2017-04-15
- Volume
- 91
- Issue
- 8
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC5375682
- OpenAlex
- W2583435206
- Cited by
- 275
- References
- 118
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 16 · 2023: 27 · 2022: 18 · 2021: 28 · 2020: 43 · 2019: 45 · 2018: 41 · 2017: 34
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (AI08725, AI073755, AI204972, P01AI106695)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- Zika virus, animal models, mouse model, nonhuman primate model, flavivirus, pathogenesis, immunity, sexual transmission, congenital Zika syndrome, Guillain-Barré syndrome, persistent infection
- MeSH terms
- Zika Virus Infection, Zika Virus, Animals, Disease Models, Animal, Primates, Mice
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