High-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses.
Open accessAbstract
Currently, there is no approved therapy to treat coronavirus infection; therefore, broad-spectrum inhibitors of emerging and endemic CoVs are needed. Based on our high-throughput screening assay using a compound library, we identified seven compounds with broad-spectrum efficacy against the replication of four CoVs in vitro . Additionally, one compound (lycorine) was found to protect BALB/c mice against HCoV-OC43-induced lethality by decreasing viral load in the central nervous system. This inhibitor might offer promising therapeutic possibilities for combatting novel CoV infections in the future.
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0.05-0.1% CPC showed potent, rapid activity against MERS-CoV and influenza viruses.
“In addition, 0.05∼0.1% CPC showed potent, rapid activity against MERS-CoV (Shen et al., 2019) and influenza viruses (Popkin et al., 2017), however it’s activity against SARS-CoV-2 is currently unknown.”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Shen et al., 2019
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References 66 · Cited by 319
- Authors
- Shen, L., Niu, J., Wang, C., Huang, B., Wang, W., Zhu, N., Deng, Y., Wang, H., Ye, F., Cen, S., & Tan, W.
- Affiliations
- Chinese Center For Disease Control and Prevention (CN)
- National Institutes for Food and Drug Control (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Tan, Wenjie
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2019-06-15
- Volume
- 93
- Issue
- 12
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC6613765
- OpenAlex
- W2924519734
- Cited by
- 319
- References
- 66
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 19 · 2023: 32 · 2022: 63 · 2021: 85 · 2020: 88 · 2019: 3 · 2015: 1
- FWCI
- 45.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Megaproject for Infectious Disease Research of China (2016ZX10004001-003)
- National Key Research and Development Program of China (2016YFD0500300, 2016YFC1200200)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Keywords
- coronavirus, high-throughput screening, lycorine, HCoV-OC43, viral replication inhibition, antiviral drug discovery
- MeSH terms
- Animals, Antiviral Agents, Cell Line, Drug Evaluation, Preclinical, Emetine, Humans, Mice, Inbred BALB C, Phenanthridines, Coronavirus, Coronavirus OC43, Human, Severe acute respiratory syndrome-related coronavirus, Amaryllidaceae Alkaloids, Mice, High-Throughput Screening Assays, Middle East Respiratory Syndrome Coronavirus
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