The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Role of CCL5 (RANTES) in Viral Lung Disease
Abstract
CCL5/RANTES is a key proinflammatory chemokine produced by virus-infected epithelial cells and present in respiratory secretions of asthmatics. To examine the role of CCL5 in viral lung disease, we measured its production during primary respiratory syncytial virus (RSV) infection and during secondary infection after sensitizing vaccination that induces Th2-mediated eosinophilia. A first peak of CCL5 mRNA and protein production was seen at 18 to 24 h of RSV infection, before significant lymphocyte recruitment occurred. Treatment in vivo with Met-RANTES (a competitive chemokine receptor blocker) throughout primary infection decreased CD4+and CD8+cell recruitment and increased viral replication. In RSV-infected, sensitized mice with eosinophilic disease, CCL5 production was further augmented; Met-RANTES treatment again reduced inflammatory cell recruitment and local cytokine production. A second wave of CCL5 production occurred on day 7, attributable to newly recruited T cells. Paradoxically, mice treated with Met-RANTES during primary infection demonstrated increased cellular infiltration during reinfection. We therefore show that RSV induces CCL5 production in the lung and this causes the recruitment of RSV-specific cells, including those making additional CCL5. If this action is blocked with Met-RANTES, inflammation decreases and viral clearance is delayed. However, the exact effects of chemokine modulation depend critically on time of administration, a factor that may potentially complicate the use of chemokine blockers in inflammatory diseases.
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“In addition to playing a distinct role in the early clinical course and persistence of SARS in infected patients, differential chemokine expression is observed in viral lung disease caused by respiratory syncytial virus (RSV) (36).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [36]
Citations
Cites
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Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES
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Self-citationCCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells
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Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation
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Immune Responses and Disease Enhancement during Respiratory Syncytial Virus Infection
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Into the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940
Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
Tregoning, J. S., & Schwarze, J. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00032-09 · Cited by 768
Self-citationPlatelets and Infection – An Emerging Role of Platelets in Viral Infection
Assinger, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00649 · Cited by 389
“CCL5 is further involved in viral lung diseases (87).”
BackgroundTargeting CCL5 in inflammation
Marques, R. E., Guabiraba, R., Russo, R. C., & Teixeira, M. M. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.837886 · Cited by 384
“However, chemokine blockade during the first phase showed opposite effects, which makes it difficult to anticipate what would be the effects of targeting this pathway in clinical studies [63].”
BackgroundPribul, P. K., Harker, J. A., Wang, B. L., Wang, H., Tregoning, J. S., Schwarze, J., & Openshaw, P. (2008) · Journal of Virology · doi:10.1128/jvi.02541-07 · Cited by 201
“tion of Met-RANTES (a competitive inhibitor) reduces both the CD4 and CD8 responses to RSV (4).”
BackgroundSelf-citation
Metadata
- Authors
- Culley, F. J., Pennycook, A. M. J., Tregoning, J. S., Dodd, J. S., Walzl, G., Wells, T. N., Hussell, T., & Openshaw, P. J. M.
- Affiliations
- Imperial College London (GB)
- Merck Serono S.A. (Switzerland) (CH)
- ORCID
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2006-08-15
- Volume
- 80
- Issue
- 16
- Pages
- 8151-8157
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2143412723
- Cited by
- 126
- References
- 40
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 8 · 2013: 3 · 2012: 9
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Virology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Funders
- Wellcome Trust (055303/Z/98/Z, 54797/Z/98/Z, 071381)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- CCL5/RANTES, respiratory syncytial virus, chemokine receptor blockade, eosinophilic inflammation, viral replication, T cell recruitment, CD4 and CD8 T cells
- MeSH terms
- Animals, Eosinophilia, Female, Mice, Inbred BALB C, Pneumonia, Viral, Respiratory Syncytial Viruses, RNA, Messenger, CD4-Positive T-Lymphocytes, Respiratory Syncytial Virus Infections, CD8-Positive T-Lymphocytes, Th2 Cells, Chemokine CCL5, Chemokines, CC, Mice
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