The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Functionally Distinct Transmission of Human Immunodeficiency Virus Type 1 Mediated by Immature and Mature Dendritic Cells
Open accessAbstract
Dendritic cells (DCs) potently stimulate the transmission of human immunodeficiency virus type 1 (HIV-1) to CD4(+) T cells. Immature DCs (iDCs) located in submucosal tissues can capture HIV-1 and migrate to lymphoid tissues, where they become mature DCs (mDCs) for effective antigen presentation. DC maturation promotes HIV-1 transmission; however, the underlying mechanisms remain unclear. Here we have compared monocyte-derived iDCs and mDCs for their efficiencies and mechanisms of HIV-1 transmission. We have found that mDCs significantly facilitate HIV-1 endocytosis and efficiently concentrate HIV-1 at virological synapses, which contributes to mDC-enhanced viral transmission, at least in part. mDCs were more efficient than iDCs in transferring HIV-1 to various types of target cells independently of C-type lectins, which partially accounted for iDC-mediated HIV-1 transmission. Efficient HIV-1 trans-infection mediated by iDCs and mDCs required contact between DCs and target cells. Moreover, rapid HIV-1 degradation occurred in both iDCs and mDCs, which correlated with the lack of HIV-1 retention-mediated long-term viral transmission. Our results provide new insights into the mechanisms underlying DC-mediated HIV-1 transmission, suggesting that HIV-1 exploits mDCs to facilitate its dissemination within lymphoid tissues.
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“In trans-infection, immature and mature DCs transmit captured HIV-1 to T cells within the first 24 h without being infected themselves [66,67,68].”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [68]
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Metadata
- Authors
- Wang, J.-H., Janas, A. M., Olson, W. J., & Wu, L.
- Affiliations
- Medical College of Wisconsin (US)
- Corresponding author
- Wu, Li
- ORCID
- Wu, Li
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2007-09
- Volume
- 81
- Issue
- 17
- Pages
- 8933-8943
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC1951429
- OpenAlex
- W2170379872
- Cited by
- 125
- References
- 58
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 5 · 2017: 3 · 2016: 6 · 2015: 8 · 2014: 11 · 2013: 12 · 2012: 16
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical College of Wisconsin
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI068493)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- HIV-1 transmission, dendritic cells, dendritic cell maturation, immature dendritic cells, monocyte-derived dendritic cells, virological synapse, C-type lectin, trans-infection, viral degradation, CD4+ T cells
- MeSH terms
- Cells, Cultured, Dendritic Cells, Endocytosis, Humans, HIV-1, Lectins, C-Type, Microscopy, Electron, Transmission, Virus Internalization
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