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Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium
Open accessAbstract
Host cell proteases that cleave the hemagglutinin (HA) of influenza viruses in the human respiratory tract are still not identified. Here we cloned two human type II transmembrane serine proteases with known airway localization, TMPRSS2 and HAT, into mammalian expression vector. Cotransfection of mammalian cells with plasmids encoding HA and either protease resulted in HA cleavage in situ. Transient expression of either protease in MDCK cells enabled multicycle replication of influenza viruses in these cells in the absence of exogenous trypsin. These data suggest that TMPRSS2 and HAT are candidates for proteolytic activation of influenza viruses in vivo.
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Citations
Cites
Role of hemagglutinin cleavage for the pathogenicity of influenza virus.
Steinhauer, D. A. (1999) · Virology · doi:10.1006/viro.1999.9716 · Cited by 663
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Metadata
- Authors
- Böttcher, E., Matrosovich, T., Beyerle, M., Klenk, H.-D., Garten, W., & Matrosovich, M.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2006-10
- Volume
- 80
- Issue
- 19
- Pages
- 9896-9898
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2099549544
- Cited by
- 489
- References
- 1
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Böttcher, E., Matrosovich, T., Beyerle, M., Klenk, H.-D., Garten, W., & Matrosovich, M. (2006). Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium. Journal of Virology. https://doi.org/10.1128/jvi.01118-06
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